Reaction profile

The FDA adverse-event record for laboured breathing

2,519 FDA adverse-event reports reference laboured breathing (VeDDRA 1171). See the species, breeds, and drugs most associated with it below.

2,519
reports citing this reaction
36.3%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
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2,519
Total Reports
915
Deaths
36.3%
Death Rate

Species Most Affected

Dog 2,039
Cat 347
Cattle 78
Horse 40
Pig 4
Other Canids 3
Sheep 3
Mouse 2
Unknown 1
Ferret 1

Breeds Most Affected

Retriever - Labrador 211
Domestic Shorthair 187
Crossbred Canine/dog 111
Retriever - Golden 87
Chihuahua 85
Shih Tzu 85
Terrier - Yorkshire 75
Shepherd Dog - German 70
Boxer (German Boxer) 58
Dog (unknown) 57

Associated Drugs

Milbemycin Oxime + Spinosad 329
Moxidectin 202
Maropitant Citrate 159
Carprofen 145
Afoxolaner 115
Bedinvetmab 107
Cefovecin 94
Prednisone 93
Trilostane 90
Spinosad 86
Fluralaner Chew Tablets 77
Oclacitinib Maleate 76
Ivermectin + Pyrantel As Pamoate Salt 76
Gabapentin 76
Milbemycin Oxime + Praziquantel 63
Famotidine 58
Selamectin 57
Pyrantel Pamoate;Sarolaner 57
Pimobendan 55
Tramadol 51

Laboured breathing Reaction Insights

2,519 reports name Laboured breathing; 915 recorded a death outcome (36.3% of reported events, not a population-level mortality rate). VeDDRA code: 1171.

By species: Dog (2,039 reports), Cat (347 reports), Cattle (78 reports). By breed: Retriever - Labrador (211), Domestic Shorthair (187), Crossbred Canine/dog (111).

Most co-reported drugs: Milbemycin Oxime + Spinosad (329 reports), Moxidectin (202 reports), Maropitant Citrate (159 reports), Carprofen (145 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.