Reaction profile

The FDA adverse-event record for haemolytic anaemia

136 FDA adverse-event reports reference haemolytic anaemia (VeDDRA 147). See the species, breeds, and drugs most associated with it below.

136
reports citing this reaction
36.8%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
136
Total Reports
50
Deaths
36.8%
Death Rate

Species Most Affected

Dog 105
Cat 26
Horse 3
Cockatiel 1
Sheep 1

Breeds Most Affected

Domestic Shorthair 14
Crossbred Canine/dog 7
Shih Tzu 7
Retriever - Labrador 6
Dog (unknown) 6
Chihuahua 5
Shepherd Dog - German 5
Schnauzer (unspecified) 4
Dachshund - Miniature 4
Schnauzer - Miniature 4

Associated Drugs

Milbemycin Oxime + Spinosad 21
Cefovecin 17
Enrofloxacin 8
Oclacitinib Maleate 8
Prednisone 7
Carprofen 7
Dexamethasone 6
Afoxolaner 6
Famotidine 5
Prednisolone 5
Fluralaner Chew Tablets 5
Dexmedetomidine Hydrochloride 4
Imidacloprid + Moxidectin 4
Moxidectin 4
Buprenorphine 4
Meloxicam 3
Ivermectin/Pyrantel Pamoate Chewable 68Mcg/163Mg 3
Fipronil 10%/S Methoprene 9% Spot On 3
Propofol 3
Diazepam 3

Haemolytic anaemia Reaction Insights

136 reports name Haemolytic anaemia; 50 recorded a death outcome (36.8% of reported events, not a population-level mortality rate). VeDDRA code: 147.

By species: Dog (105 reports), Cat (26 reports), Horse (3 reports). By breed: Domestic Shorthair (14), Crossbred Canine/dog (7), Shih Tzu (7).

Most co-reported drugs: Milbemycin Oxime + Spinosad (21 reports), Cefovecin (17 reports), Enrofloxacin (8 reports), Oclacitinib Maleate (8 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.