Reaction profile

The FDA adverse-event record for application site scab

2,536 FDA adverse-event reports reference application site scab (VeDDRA 15). See the species, breeds, and drugs most associated with it below.

2,536
reports citing this reaction
0.9%
death-coded share
Cat
most-affected species
Selamectin
most-associated drug
Verify with FDA CVM →
2,536
Total Reports
23
Deaths
0.9%
Death Rate

Species Most Affected

Cat 2,305
Dog 224
Cattle 4
Goat 1
Human 1
Horse 1

Breeds Most Affected

Domestic Shorthair 1,604
Domestic Longhair 163
Domestic Mediumhair 141
Cat (other) 99
Siamese 56
Cat (unknown) 52
Maine Coon 44
Bengal 25
Ragdoll 18
Shih Tzu 16

Associated Drugs

Selamectin 805
Selamectin;Sarolaner 636
Fluralaner Spot-On Solution 325
Imidacloprid + Moxidectin 272
Emodepside + Praziquantel 177
Fluralaner/Moxidectin Spot-On 82
Flumethrin-Imidacloprid 49
Eprinomectin + Esafoxolaner + Praziquantel 45
Buprenorphine 39
Mirtazapine 37
Cefovecin 33
Cefovecin Sodium 33
Ivermectin + Pyrantel As Pamoate Salt 31
Methylprednisolone Acetate 26
Imidacloprid, Flumethrin 22
Fipronil 10%/S Methoprene 9% Spot On 16
Robenacoxib 16
Nitenpyram 13
Rabies Vaccine 13
Fipronil 9.8%/S-Methoprene 8.8%/ Amitraz 22.1% Spot-On 12

Application site scab Reaction Insights

2,536 reports name Application site scab; 23 recorded a death outcome (0.9% of reported events, not a population-level mortality rate). VeDDRA code: 15.

By species: Cat (2,305 reports), Dog (224 reports), Cattle (4 reports). By breed: Domestic Shorthair (1,604), Domestic Longhair (163), Domestic Mediumhair (141).

Most co-reported drugs: Selamectin (805 reports), Selamectin;Sarolaner (636 reports), Fluralaner Spot-On Solution (325 reports), Imidacloprid + Moxidectin (272 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.