Reaction profile

The FDA adverse-event record for application site scab

2,645 FDA reports name application site scab, a high-volume reaction in the CVM extract (VeDDRA 15). Plate stamps and neighbourhood peers follow.

#180 of 2,481
by report volume (all reactions)
2,645
reports citing this reaction
0.9%
death-coded share
Cat
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Application site scab has 2,645 reports now versus 2,600 in that prior snapshot: 45 more (1.7%).

Report change
+45
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Application site scab changes

FDA AER · VeDDRA plate

Code 15 VOL-MID

VOL-MID · DEATH-RARE · TOP-DECILE · PHOTO-FINISH · SPECIES-CAT · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 2,645 reports
  • DEATH-RARE 0.9%
  • TOP-DECILE #180/2481
  • PHOTO-FINISH Breathing difficulty
  • SPECIES-CAT Cat · 2,399
  • DRUG-LEAD Selamectin · 813
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Breathing difficulty (±5 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Application site scab

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Bradycardia · near2681Application site scab · this…2645Breathing difficulty · near2640Haematuria · near2626Laboured breathing · near2623Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Application site scab

Application site scab: low death-coded share in the FDA AER plate

Signature read: 2,645 reports place Application site scab in the upper third of FDA AER volume (#180 of 2,481). Report volume is upper-third scale: 2,645 named reports in the openFDA extract. Death-coded share is lower-third: 23 of 2,645 reports (0.9% of named reports). Nearest volume peer: Breathing difficulty (±5 reports). Lead species Cat (2,399). Lead co-reported drug Selamectin (813).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Selamectin appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Cat 2,399
Dog 239
Cattle 4
Goat 1
Human 1
Horse 1

Breeds Most Affected

Domestic Shorthair 1,674
Domestic Longhair 169
Domestic Mediumhair 143
Cat (other) 103
Siamese 57
Cat (unknown) 55
Maine Coon 45
Bengal 25
Crossbred Canine/dog 18
Ragdoll 18

Associated Drugs

Selamectin 813
Selamectin;Sarolaner 684
Fluralaner Spot-On Solution 328
Imidacloprid + Moxidectin 273
Emodepside + Praziquantel 177
Fluralaner/Moxidectin Spot-On 93
Eprinomectin + Esafoxolaner + Praziquantel 52
Flumethrin-Imidacloprid 49
Mirtazapine 48
Buprenorphine 46
Cefovecin Sodium 34
Cefovecin 33
Ivermectin + Pyrantel As Pamoate Salt 31
Methylprednisolone Acetate 26
Imidacloprid, Flumethrin 22
Robenacoxib 20
Maropitant Citrate 17
Fipronil 10%/S Methoprene 9% Spot On 16
Isoflurane 15
Prednisone 13

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Application site scab, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (2,645 here).

Similar death-coded share

Nearest other reactions by death-coded share (0.9% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Application site scab (#180 of 2,481 by report volume); death-coded 0.9%. PlainBreed reaction plate · report volume stamp 2,645 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →