Reaction profile

The FDA adverse-event record for cloudy eye (for miosis, mydriasis, anisocoria, nystagmus - see 'neurological')

227 FDA adverse-event reports reference cloudy eye (for miosis, mydriasis, anisocoria, nystagmus - see 'neurological') (VeDDRA 445). See the species, breeds, and drugs most associated with it below.

227
reports citing this reaction
11.5%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
227
Total Reports
26
Deaths
11.5%
Death Rate

Species Most Affected

Dog 183
Cat 27
Cattle 15
Human 1
Mouse 1

Breeds Most Affected

Domestic Shorthair 17
Crossbred Canine/dog 16
Retriever - Labrador 12
Shih Tzu 11
Chihuahua 11
Terrier - Yorkshire 8
Pinscher - Miniature 7
Shepherd Dog - German 5
Spitz - German Pomeranian 5
Shepherd Dog - Australian 5

Associated Drugs

Milbemycin Oxime + Spinosad 29
Spinosad 15
Imidacloprid + Moxidectin 15
Carprofen 13
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 10
Moxidectin 9
Hyaluronic Acid 9
Fluralaner Chew Tablets 9
Milbemycin Oxime + Praziquantel 9
Prednisone 8
Ivermectin 7
Insulin Injectable Vial 7
Sarolaner 7
Recombinant Human Insulin 6
Robenacoxib 6
Maropitant Citrate 6
Meloxicam 5
Diphenhydramine 5
Oclacitinib Maleate 5
Afoxolaner 5

Cloudy eye (for Miosis, Mydriasis, Anisocoria, Nystagmus - see 'Neurological') Reaction Insights

227 reports name Cloudy eye (for Miosis, Mydriasis, Anisocoria, Nystagmus - see 'Neurological'); 26 recorded a death outcome (11.5% of reported events, not a population-level mortality rate). VeDDRA code: 445.

By species: Dog (183 reports), Cat (27 reports), Cattle (15 reports). By breed: Domestic Shorthair (17), Crossbred Canine/dog (16), Retriever - Labrador (12).

Most co-reported drugs: Milbemycin Oxime + Spinosad (29 reports), Spinosad (15 reports), Imidacloprid + Moxidectin (15 reports), Carprofen (13 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.