Reaction profile

The FDA adverse-event record for allergic oedema

74 FDA adverse-event reports reference allergic oedema (VeDDRA 515). See the species, breeds, and drugs most associated with it below.

74
reports citing this reaction
4.1%
death-coded share
Dog
most-affected species
Moxidectin
most-associated drug
Verify with FDA CVM →
74
Total Reports
3
Deaths
4.1%
Death Rate

Species Most Affected

Dog 50
Horse 13
Human 4
Cattle 3
Cat 3
Bat 1

Breeds Most Affected

Unknown 7
Retriever - Labrador 6
Quarter Horse 5
Shepherd Dog - Australian 4
Dachshund (unspecified) 4
Chihuahua 3
Mixed (Dog) 3
Boxer (German Boxer) 3
Horse (unknown) 3
Weimaraner 2

Associated Drugs

Moxidectin 14
Isoflurane 6
Milbemycin Oxime + Spinosad 5
Butorphanol 4
Fluralaner 13.64% 12-Week Chew 4
Imidacloprid + Moxidectin 3
Carprofen 3
Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St 3
Polysulfated Glycosaminoglycan 3
Afoxolaner 3
Diphenhydramine 3
Fluralaner Spot-On Solution 3
Alfaxalone 3
Praziquantel;Moxidectin 3
Melarsomine 2
Glycosaminoglycan Polysulfate 2
Enrofloxacin 2
Ceftiofur Crystalline Free Acid 2
Spinosad 2
Borrelia Burgdorferi Strain Ips 930-34-081596; Borrelia Burgdorferi Strain B-31 2

Allergic oedema Reaction Insights

74 reports name Allergic oedema; 3 recorded a death outcome (4.1% of reported events, not a population-level mortality rate). VeDDRA code: 515.

By species: Dog (50 reports), Horse (13 reports), Human (4 reports). By breed: Unknown (7), Retriever - Labrador (6), Quarter Horse (5).

Most co-reported drugs: Moxidectin (14 reports), Isoflurane (6 reports), Milbemycin Oxime + Spinosad (5 reports), Butorphanol (4 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.