Reaction profile

The FDA adverse-event record for downer animal

151 FDA adverse-event reports reference downer animal (VeDDRA 2172). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1178 of 2,481
by report volume (all reactions)
151
reports citing this reaction
72.2%
death-coded share
Cattle
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Downer animal has 151 reports now versus 149 in that prior snapshot: 2 more (1.3%).

Report change
+2
Death-coded reports
+0
Death-coded share
−1.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Downer animal changes

FDA AER · VeDDRA plate

Code 2172 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-CATTLE · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 151 reports
  • DEATH-HOT 72.2%
  • MID-PACK #1178/2481
  • PHOTO-FINISH Bulging eye
  • SPECIES-CATTLE Cattle · 92
  • DRUG-LEAD Doramectin · 10
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Bulging eye (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Report-volume neighbourhood around Downer animal

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Bulging eye · near151Downer animal · this reaction151Haemoptysis · near151Injection site granul… · near151Joint stiffness · near151Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Downer animal

Downer animal: high death-coded share in the FDA AER plate

Signature read: Downer animal's 72.2% death-coded share is among the highest in the openFDA reaction corpus. Report volume sits in the middle third of the reaction corpus. Death-coded share is upper-third: 109 of 151 reports (72.2% of named reports). Nearest volume peer: Bulging eye (±0 reports). Lead species Cattle (92). Lead co-reported drug Doramectin (10).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Cattle 92
Dog 25
Horse 15
Pig 7
Cat 4
Alpaca 2
Goat 2
Other Birds 1
Other Mammals 1
Chicken 1

Breeds Most Affected

Cattle (other) 24
Holstein-Friesian also known as Holstein 16
Mixed (Cattle) 12
Aberdeen Angus 10
Unknown 8
Jersey 7
Crossbred Bovine/Cattle 6
Quarter Horse 5
Pig (unknown) 5
Cattle (unknown) 5

Associated Drugs

Doramectin 10
Ceftiofur Crystalline Free Acid 10
Monensin Sodium 10
Ivermectin 9
Moxidectin 8
Carprofen 8
Bedinvetmab 8
Dinoprost Tromethamine 7
Tulathromycin 5
Prednisone 5
Clorsulon + Ivermectin 4
Trenbolone Acet/Estradiol Impl 4
Eprinomectin 4
Florfenicol 4
Cloxacillin Benz Intramam Dc 4
Dexamethasone 4
Cloxacillin Benzathine 3
Fenbendazol Suspension 3
Tiamulin 3
Ceftiofur Hydrochloride 3

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Downer animal, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (151 here).

Similar death-coded share

Nearest other reactions by death-coded share (72.2% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Downer animal (#1178 of 2,481 by report volume); death-coded 72.2%. PlainBreed reaction plate · death-coded share stamp 72.2% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →