Reaction profile

The FDA adverse-event record for bulging eye

151 FDA adverse-event reports reference bulging eye (VeDDRA 2380). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1177 of 2,481
by report volume (all reactions)
151
reports citing this reaction
19.2%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Bulging eye has 151 reports now versus 149 in that prior snapshot: 2 more (1.3%).

Report change
+2
Death-coded reports
+1
Death-coded share
+0.4 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Bulging eye changes

FDA AER · VeDDRA plate

Code 2380 VOL-LOW

VOL-LOW · DEATH-ELEV · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 151 reports
  • DEATH-ELEV 19.2%
  • MID-PACK #1177/2481
  • PHOTO-FINISH Downer animal
  • SPECIES-DOG Dog · 134
  • DRUG-LEAD Afoxolaner · 24
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Downer animal (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Bulging eye

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Bulging eye · this reaction151Downer animal · near151Haemoptysis · near151Injection site granul… · near151Joint stiffness · near151Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Bulging eye

What the FDA AER plate says about Bulging eye

Signature read: 29 death-coded reports is the most distinctive absolute-outcome stamp on Bulging eye. Report volume sits in the middle third of the reaction corpus. 29 of 151 reports were death-coded (19.2% of named reports, not a population mortality rate). Nearest volume peer: Downer animal (±0 reports). Lead species Dog (134). Lead co-reported drug Afoxolaner (24).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Afoxolaner appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 134
Cat 15
Goat 1
Horse 1

Breeds Most Affected

Shih Tzu 9
Bulldog - French 9
Crossbred Canine/dog 8
Retriever - Labrador 7
Domestic Shorthair 7
Chihuahua 6
Terrier - Yorkshire 6
Shepherd Dog - Australian 6
Pekingese 6
Collie - Border 5

Associated Drugs

Afoxolaner 24
Ivermectin + Pyrantel As Pamoate Salt 13
Pyrantel Pamoate;Sarolaner 12
Oclacitinib Maleate 10
Trilostane 10
Maropitant Citrate 7
Carprofen 7
Prednisone 7
Fluralaner 13.64% 12-Week Chew 7
Milbemycin Oxime + Spinosad 6
Imidacloprid + Moxidectin 5
Cefovecin 5
Sarolaner 5
Bedinvetmab 5
Anesthetic 4
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 4
Cyclosporine 4
Fluralaner Chew Tablets 3
Milbemycin Oxime 3
Buprenorphine 3

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Bulging eye, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (151 here).

Similar death-coded share

Nearest other reactions by death-coded share (19.2% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Bulging eye (#1177 of 2,481 by report volume); death-coded 19.2%. PlainBreed reaction plate · death-coded report count stamp 29 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →