Reaction profile

The FDA adverse-event record for intentional misuse

3,154 FDA adverse-event reports reference intentional misuse (VeDDRA 3039). See the species, breeds, and drugs most associated with it below.

3,154
reports citing this reaction
7.8%
death-coded share
Dog
most-affected species
Pyrantel Pamoate;Sarolaner
most-associated drug
Verify with FDA CVM →
3,154
Total Reports
246
Deaths
7.8%
Death Rate

Species Most Affected

Dog 2,594
Cat 454
Horse 39
Cattle 33
Human 9
Goat 7
Unknown 3
Pig 3
Sheep 2
Lynx 1

Breeds Most Affected

Retriever - Labrador 340
Domestic Shorthair 267
Retriever - Golden 190
Crossbred Canine/dog 153
Dog (unknown) 124
Shepherd Dog - German 113
Terrier - Bull - American Pit 110
Shepherd Dog - Australian 87
Chihuahua 86
Terrier - Yorkshire 66

Associated Drugs

Pyrantel Pamoate;Sarolaner 1,185
Moxidectin 515
Bedinvetmab 359
Oclacitinib Maleate 293
Maropitant Citrate 259
Cefovecin 190
Carprofen 169
Frunevetmab 161
Gabapentin 152
Recombinant E. Coli Bl21;Recombinant E. Coli Ecl19 150
Sarolaner 88
Anti-Il31 Mab Mcs Lot #1283563 72
Dexmedetomidine Hydrochloride 65
Selamectin;Sarolaner 57
Amoxicillin Trihydrate;Clavulanate Potassium ( K-Clavulanate) 53
Selamectin 51
Buprenorphine 45
Doxycycline 44
Midazolam 39
Butorphanol Tartrate 39

Intentional misuse Reaction Insights

3,154 reports name Intentional misuse; 246 recorded a death outcome (7.8% of reported events, not a population-level mortality rate). VeDDRA code: 3039.

By species: Dog (2,594 reports), Cat (454 reports), Horse (39 reports). By breed: Retriever - Labrador (340), Domestic Shorthair (267), Retriever - Golden (190).

Most co-reported drugs: Pyrantel Pamoate;Sarolaner (1,185 reports), Moxidectin (515 reports), Bedinvetmab (359 reports), Oclacitinib Maleate (293 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.