Reaction profile

The FDA adverse-event record for injection site mass nos

171 FDA adverse-event reports reference injection site mass nos (VeDDRA 2113). See the species, breeds, and drugs most associated with it below.

171
reports citing this reaction
8.2%
death-coded share
Dog
most-affected species
Moxidectin
most-associated drug
Verify with FDA CVM →
171
Total Reports
14
Deaths
8.2%
Death Rate

Species Most Affected

Dog 135
Cat 35
Mouse 1

Breeds Most Affected

Domestic Shorthair 26
Retriever - Golden 17
Retriever - Labrador 15
Shepherd Dog - German 8
Dog (unknown) 6
Domestic Longhair 6
Boxer (German Boxer) 5
Crossbred Canine/dog 5
Terrier - Bull - American Pit 5
Chihuahua 4

Associated Drugs

Moxidectin 49
Melarsomine Dihydrochloride 28
Bedinvetmab 21
Tigilanol Tiglate 15
Frunevetmab 14
Gabapentin 13
Robenacoxib 11
Buprenorphine 10
Diphenhydramine 10
Carprofen 9
Rabies Vaccine, Killed Virus 7
Cefovecin 7
Prednisone 7
Rabies Vaccine 6
Maropitant Citrate 6
Butorphanol 5
Dexmedetomidine 5
Oclacitinib Maleate 5
Famotidine 5
Milbemycin Oxime + Praziquantel 4

Injection site mass NOS Reaction Insights

171 reports name Injection site mass NOS; 14 recorded a death outcome (8.2% of reported events, not a population-level mortality rate). VeDDRA code: 2113.

By species: Dog (135 reports), Cat (35 reports), Mouse (1 reports). By breed: Domestic Shorthair (26), Retriever - Golden (17), Retriever - Labrador (15).

Most co-reported drugs: Moxidectin (49 reports), Melarsomine Dihydrochloride (28 reports), Bedinvetmab (21 reports), Tigilanol Tiglate (15 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.