Reaction profile

The FDA adverse-event record for erythema (for urticaria see immune soc)

4,428 FDA adverse-event reports reference erythema (for urticaria see immune soc) (VeDDRA 948). See the species, breeds, and drugs most associated with it below.

4,428
reports citing this reaction
3.0%
death-coded share
Dog
most-affected species
Moxidectin
most-associated drug
Verify with FDA CVM →
4,428
Total Reports
133
Deaths
3.0%
Death Rate

Species Most Affected

Dog 3,926
Cat 385
Human 82
Horse 14
Cattle 7
Pig 6
Rabbit 4
Turkey 1
Donkey 1
Ferret 1

Breeds Most Affected

Retriever - Labrador 378
Domestic Shorthair 250
Chihuahua 227
Crossbred Canine/dog 215
Terrier - Bull - American Pit 207
Terrier - Yorkshire 152
Boxer (German Boxer) 140
Shih Tzu 138
Shepherd Dog - German 128
Pit Bull 128

Associated Drugs

Moxidectin 673
Afoxolaner 626
Milbemycin Oxime + Spinosad 317
Oclacitinib Maleate 270
Imidacloprid + Moxidectin 251
Maropitant Citrate 193
Carprofen 170
Selamectin 168
Ivermectin + Pyrantel As Pamoate Salt 168
Anti-Il31 Mab Mcs Lot #1283563 144
Fluralaner Chew Tablets 143
Cefovecin 142
Prednisone 138
Diphenhydramine Hcl 115
Spinosad 112
Phenylpropanolamine Hcl 106
Diphenhydramine 84
Dexamethasone 82
Enrofloxacin 70
Rabies Virus, Kv 70

Erythema (for urticaria see Immune SOC) Reaction Insights

4,428 reports name Erythema (for urticaria see Immune SOC); 133 recorded a death outcome (3.0% of reported events, not a population-level mortality rate). VeDDRA code: 948.

By species: Dog (3,926 reports), Cat (385 reports), Human (82 reports). By breed: Retriever - Labrador (378), Domestic Shorthair (250), Chihuahua (227).

Most co-reported drugs: Moxidectin (673 reports), Afoxolaner (626 reports), Milbemycin Oxime + Spinosad (317 reports), Oclacitinib Maleate (270 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.