Reaction profile

The FDA adverse-event record for nausea

4,502 FDA reports name nausea, a high-volume reaction in the CVM extract (VeDDRA 1638). Plate stamps and neighbourhood peers follow.

#108 of 2,481
by report volume (all reactions)
4,502
reports citing this reaction
7.4%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Nausea has 4,502 reports now versus 4,427 in that prior snapshot: 75 more (1.7%).

Report change
+75
Death-coded reports
+7
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Nausea changes

FDA AER · VeDDRA plate

Code 1638 VOL-MID

VOL-MID · DEATH-PAR · TOP-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 4,502 reports
  • DEATH-PAR 7.4%
  • TOP-DECILE #108/2481
  • PHOTO-FINISH Erythema (for urticar…
  • SPECIES-DOG Dog · 3,586
  • DRUG-LEAD Milbemycin Oxime… · 995
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Erythema (for urticaria see Immune SOC) (±7 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Nausea

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Falling · near4570Hyperphosphataemia · near4554Erythema (for urticar… · near4509Nausea · this reaction4502Intentional misuse · near4443Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Nausea

Nausea: low death-coded share in the FDA AER plate

Signature read: 4,502 reports place Nausea in the upper third of FDA AER volume (#108 of 2,481). Report volume is upper-third scale: 4,502 named reports in the openFDA extract. Death-coded share is lower-third: 333 of 4,502 reports (7.4% of named reports). Nearest volume peer: Erythema (for urticaria see Immune SOC) (±7 reports). Lead species Dog (3,586). Lead co-reported drug Milbemycin Oxime + Spinosad (995).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 3,586
Cat 463
Human 442
Horse 3
Monkey 2
Other Canids 1
Pig 1
Cattle 1
Ferret 1
Unknown 1

Breeds Most Affected

Unknown 460
Retriever - Labrador 382
Crossbred Canine/dog 261
Domestic Shorthair 245
Dog (unknown) 192
Chihuahua 167
Retriever - Golden 146
Terrier - Yorkshire 137
Boxer (German Boxer) 127
Shih Tzu 106

Associated Drugs

Milbemycin Oxime + Spinosad 995
Maropitant Citrate 319
Spinosad 278
Carprofen 217
Afoxolaner 189
Pyrantel Pamoate;Sarolaner 183
Gabapentin 164
Oclacitinib Maleate 142
Moxidectin 141
Ivermectin + Pyrantel As Pamoate Salt 138
Bedinvetmab 127
Milbemycin Oxime + Praziquantel 120
Fluralaner Chew Tablets 116
Selamectin 103
Prednisone 97
Grapiprant 95
Trilostane 91
Polysulfated Glycosaminoglycan 91
Cyclosporine 90
Buprenorphine 82

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Nausea, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (4,502 here).

Similar death-coded share

Nearest other reactions by death-coded share (7.4% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Nausea (#108 of 2,481 by report volume); death-coded 7.4%. PlainBreed reaction plate · report volume stamp 4,502 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →