Reaction profile

The FDA adverse-event record for nausea

4,316 FDA adverse-event reports reference nausea (VeDDRA 1638). See the species, breeds, and drugs most associated with it below.

4,316
reports citing this reaction
7.3%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
4,316
Total Reports
317
Deaths
7.3%
Death Rate

Species Most Affected

Dog 3,447
Human 434
Cat 425
Horse 3
Monkey 2
Other Canids 1
Pig 1
Cattle 1
Ferret 1
Unknown 1

Breeds Most Affected

Unknown 450
Retriever - Labrador 361
Crossbred Canine/dog 254
Domestic Shorthair 226
Dog (unknown) 185
Chihuahua 163
Retriever - Golden 142
Terrier - Yorkshire 133
Boxer (German Boxer) 124
Shih Tzu 106

Associated Drugs

Milbemycin Oxime + Spinosad 994
Maropitant Citrate 285
Spinosad 278
Carprofen 204
Afoxolaner 183
Pyrantel Pamoate;Sarolaner 168
Gabapentin 144
Oclacitinib Maleate 138
Ivermectin + Pyrantel As Pamoate Salt 136
Moxidectin 134
Fluralaner Chew Tablets 116
Milbemycin Oxime + Praziquantel 114
Bedinvetmab 113
Selamectin 99
Prednisone 90
Grapiprant 88
Trilostane 87
Polysulfated Glycosaminoglycan 87
Cyclosporine 85
Sarolaner 77

Nausea Reaction Insights

4,316 reports name Nausea; 317 recorded a death outcome (7.3% of reported events, not a population-level mortality rate). VeDDRA code: 1638.

By species: Dog (3,447 reports), Human (434 reports), Cat (425 reports). By breed: Unknown (450), Retriever - Labrador (361), Crossbred Canine/dog (254).

Most co-reported drugs: Milbemycin Oxime + Spinosad (994 reports), Maropitant Citrate (285 reports), Spinosad (278 reports), Carprofen (204 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.