Reaction profile

The FDA adverse-event record for injection site weeping (see also skin)

91 FDA adverse-event reports reference injection site weeping (see also skin) (VeDDRA 103). See the species, breeds, and drugs most associated with it below.

91
reports citing this reaction
9.9%
death-coded share
Dog
most-affected species
Tigilanol Tiglate
most-associated drug
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91
Total Reports
9
Deaths
9.9%
Death Rate

Species Most Affected

Dog 90
Cat 1

Breeds Most Affected

Retriever - Labrador 11
Retriever - Golden 10
Boxer (German Boxer) 10
Bulldog - French 6
Pit Bull 5
Terrier (unspecified) 4
Chihuahua 3
Shepherd Dog - German 3
Corgi - Welsh Cardigan 3
Hound (unspecified) 2

Associated Drugs

Tigilanol Tiglate 69
Gabapentin 26
Famotidine 25
Diphenhydramine 21
Dexmedetomidine 21
Prednisone 20
Butorphanol 18
Butorphanol Tartrate 15
Maropitant Citrate 13
Atipamezole Hydrochloride 8
Dexmedetomidine Hydrochloride 7
Meloxicam 7
Atipamezole 6
Buprenorphine 5
Alfaxalone 5
Bedinvetmab 4
Carprofen 4
Propofol 4
Hydromorphone 3
Prednisolone 3

Injection site weeping (see also Skin) Reaction Insights

91 reports name Injection site weeping (see also Skin); 9 recorded a death outcome (9.9% of reported events, not a population-level mortality rate). VeDDRA code: 103.

By species: Dog (90 reports), Cat (1 reports). By breed: Retriever - Labrador (11), Retriever - Golden (10), Boxer (German Boxer) (10).

Most co-reported drugs: Tigilanol Tiglate (69 reports), Gabapentin (26 reports), Famotidine (25 reports), Diphenhydramine (21 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.