Reaction profile

The FDA adverse-event record for droopy lower lip

75 FDA adverse-event reports reference droopy lower lip (VeDDRA 2454). See the species, breeds, and drugs most associated with it below.

75
reports citing this reaction
5.3%
death-coded share
Dog
most-affected species
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride
most-associated drug
Verify with FDA CVM →
75
Total Reports
4
Deaths
5.3%
Death Rate

Species Most Affected

Dog 67
Horse 7
Cat 1

Breeds Most Affected

Shepherd Dog - German 7
Beagle 6
Retriever - Labrador 4
Crossbred Canine/dog 4
Pit Bull 4
Terrier - Bull - American Pit 3
Quarter Horse 3
Spaniel - Cocker American 3
Boxer (German Boxer) 3
Retriever - Golden 2

Associated Drugs

Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 15
Trilostane 12
Bedinvetmab 8
Afoxolaner 6
Milbemycin Oxime + Spinosad 5
Fluralaner Chew Tablets 5
Ear Cleaner 5
Prednisone 5
Oclacitinib Maleate 4
Fish Oil 4
Maropitant Citrate 4
Carprofen 4
Gabapentin 4
Pyrantel Pamoate;Sarolaner 4
Florfenicol, Terbinafine, Betamethasone Acetate 4
Ketoconazole 4
Marbofloxacin 3
Ear Cleaner (Unknown) 3
Cyclosporine 3
Thiabendazole, Dexamethasone, Neomycin Sulfate 2

Droopy lower lip Reaction Insights

75 reports name Droopy lower lip; 4 recorded a death outcome (5.3% of reported events, not a population-level mortality rate). VeDDRA code: 2454.

By species: Dog (67 reports), Horse (7 reports), Cat (1 reports). By breed: Shepherd Dog - German (7), Beagle (6), Retriever - Labrador (4).

Most co-reported drugs: Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride (15 reports), Trilostane (12 reports), Bedinvetmab (8 reports), Afoxolaner (6 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.