Reaction profile

The FDA adverse-event record for ketosis

2,637 FDA adverse-event reports reference ketosis (VeDDRA 567). See the species, breeds, and drugs most associated with it below.

2,637
reports citing this reaction
8.5%
death-coded share
Cat
most-affected species
Bexagliflozin
most-associated drug
Verify with FDA CVM →
2,637
Total Reports
224
Deaths
8.5%
Death Rate

Species Most Affected

Cat 2,589
Dog 24
Cattle 23
Lynx 1

Breeds Most Affected

Domestic Shorthair 1,758
Domestic Longhair 240
Cat (unknown) 216
Domestic Mediumhair 159
Siamese 53
Maine Coon 50
Holstein-Friesian also known as Holstein 17
Ragdoll 15
Russian 15
American Shorthair 8

Associated Drugs

Bexagliflozin 1,429
Velagliflozin Proline Monohydrate 1,089
Prescription Diet 96
Maropitant Citrate 69
Gabapentin 67
Senvelgo Velagliflozin Oral Solution 53
Fluid Therapy 50
Cefovecin Sodium 45
Insulin 41
Frunevetmab 34
Methimazole 29
Prednisolone 26
Dextrose 25
Robenacoxib 23
Dietary Supplement 21
Mirtazapine 21
Amoxicillin + Clavulanic Acid 20
Cyclosporine 20
Metronidazole 19
Prescription Diet (Unknown) 18

Ketosis Reaction Insights

2,637 reports name Ketosis; 224 recorded a death outcome (8.5% of reported events, not a population-level mortality rate). VeDDRA code: 567.

By species: Cat (2,589 reports), Dog (24 reports), Cattle (23 reports). By breed: Domestic Shorthair (1,758), Domestic Longhair (240), Cat (unknown) (216).

Most co-reported drugs: Bexagliflozin (1,429 reports), Velagliflozin Proline Monohydrate (1,089 reports), Prescription Diet (96 reports), Maropitant Citrate (69 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.