Reaction profile

The FDA adverse-event record for injection site bruising

507 FDA adverse-event reports reference injection site bruising (VeDDRA 79). See the species, breeds, and drugs most associated with it below.

507
reports citing this reaction
8.1%
death-coded share
Dog
most-affected species
Tigilanol Tiglate
most-associated drug
Verify with FDA CVM →
507
Total Reports
41
Deaths
8.1%
Death Rate

Species Most Affected

Dog 391
Human 96
Cat 10
Pig 2
Cattle 2
Ferret 1
Guinea Pig 1
Rabbit 1
Mouse 1
Horse 1

Breeds Most Affected

Unknown 98
Retriever - Labrador 36
Dog (unknown) 29
Pit Bull 29
Retriever - Golden 23
Maltese 20
Chihuahua 20
Boxer (German Boxer) 18
Terrier - Boston 10
Crossbred Canine/dog 9

Associated Drugs

Tigilanol Tiglate 201
Maropitant Citrate 53
Diphenhydramine 51
Carprofen 48
Famotidine 47
Gabapentin 42
Prednisone 38
Moxidectin 37
Butorphanol 25
Dexmedetomidine 23
Butorphanol Tartrate 20
Dexmedetomidine Hydrochloride 20
Propofol 20
Atipamezole 19
Bupivacaine 19
Buprenorphine 18
Melarsomine Dihydrochloride 18
Enrofloxacin 13
Hydromorphone 13
Polysulfated Glycosaminoglycan 12

Injection site bruising Reaction Insights

507 reports name Injection site bruising; 41 recorded a death outcome (8.1% of reported events, not a population-level mortality rate). VeDDRA code: 79.

By species: Dog (391 reports), Human (96 reports), Cat (10 reports). By breed: Unknown (98), Retriever - Labrador (36), Dog (unknown) (29).

Most co-reported drugs: Tigilanol Tiglate (201 reports), Maropitant Citrate (53 reports), Diphenhydramine (51 reports), Carprofen (48 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.