INEFFECTIVE, WHIPS

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VeDDRA Code: 99158

2,007 adverse event reports referencing this reaction

2,007
Total Reports
6
Deaths
30.0%
Death Rate

Species Most Affected

Dog 2,000
Pig 2
Cattle 2
Cat 2
Other Canids 1

Breeds Most Affected

Retriever - Labrador 253
Retriever - Golden 150
Crossbred Canine/dog 129
Shepherd Dog - German 105
Beagle 85
Shepherd Dog - Australian 59
Dachshund (unspecified) 58
Dog (unknown) 54
Pit Bull 51
Collie - Border 49

Associated Drugs

Ivermectin + Pyrantel As Pamoate Salt 767
Milbemycin Oxime + Praziquantel 515
Milbemycin Oxime + Spinosad 190
Moxidectin 154
Lufenuron + Milbemycin Oxime 151
Imidacloprid + Moxidectin 90
Milbemycin Oxime 75
Lufenuron + Milbemycin Oxime + Praziquantel 67
Milbemycin Oxime, Lufenuron 54
Selamectin 28
Afoxolaner 20
Fluralaner 16
Fenbendazole 15
Milbemcyin Oxime, Lufenuron, Praziquantel 14
Ivermectin + Pyrantel 13
Febantel + Praziquantel + Pyrantel Pamoate 13
Milbemycin/Lufenuron Tablets 13
Sarolaner 10
Milbemycin/Lufenuron/Pzq Chew 8
Ivermectin 7

Data Summary

Metric Value
Total reports referencing reaction 2,007
Reports with fatal outcome 6
Case-fatality rate (reported events) 30.0%
Species observed 5
Breeds observed 20
Drugs associated with reaction 20

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER); reaction term coded under VeDDRA 99158.

INEFFECTIVE, WHIPS Reaction Insights

The FDA Center for Veterinary Medicine database currently lists 2,007 adverse event reports that reference INEFFECTIVE, WHIPS as a reaction term, including 6 reports with a death outcome — a 30.0% case-fatality figure calculated across only those events where this reaction was coded. The reaction is indexed in the openFDA system under VeDDRA code 99158, the standardized veterinary dictionary used to normalize clinical signs across submitters. Because reports are voluntary and often describe multiple concurrent signs per animal, the volume here reflects reporting intensity rather than true incidence in the broader pet population.

INEFFECTIVE, WHIPS appears most frequently in reports for Dog (2,000 reports), Pig (2 reports), Cattle (2 reports) — with Dog dominating at 2,000 entries. Within those species, the breeds most often named alongside this reaction are Retriever - Labrador (253), Retriever - Golden (150), Crossbred Canine/dog (129). These distributions are influenced both by underlying breed popularity and by how veterinarians and owners code a given clinical sign, so they should be interpreted as a reporting fingerprint rather than a pure susceptibility ranking.

The drugs most commonly co-reported with INEFFECTIVE, WHIPS are Ivermectin + Pyrantel As Pamoate Salt (767 reports), Milbemycin Oxime + Praziquantel (515 reports), Milbemycin Oxime + Spinosad (190 reports), Moxidectin (154 reports), with Ivermectin + Pyrantel As Pamoate Salt appearing alongside this reaction in 767 submissions. Co-reporting does not establish that any specific product caused the reaction — FDA CVM data captures temporal association only. The value of these aggregates is in flagging which therapeutic classes appear repeatedly alongside a given clinical sign, so owners and veterinarians can ask targeted questions about medications currently in use.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial