Reaction profile

The FDA adverse-event record for ineffective, hooks

13,039 FDA reports name ineffective, hooks, a high-volume reaction in the CVM extract (VeDDRA 99112). Plate stamps and neighbourhood peers follow.

#32 of 2,481
by report volume (all reactions)
13,039
reports citing this reaction
0.3%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. INEFFECTIVE, HOOKS has 13,039 reports now versus 13,039 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to INEFFECTIVE, HOOKS changes

FDA AER · VeDDRA plate

Code 99112 VOL-HIGH

VOL-HIGH · DEATH-RARE · TOP-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-HIGH 13,039 reports
  • DEATH-RARE 0.3%
  • TOP-DECILE #32/2481
  • PHOTO-FINISH Depression
  • SPECIES-DOG Dog · 12,986
  • DRUG-LEAD Ivermectin + Pyra… · 6,534
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Depression (±21 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around INEFFECTIVE, HOOKS

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Depression · near13060INEFFECTIVE, HOOKS · this re…13039Containers, Damaged · near13017Accidental exposure · near12968Shaking · near12949Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around INEFFECTIVE, HOOKS

INEFFECTIVE, HOOKS: low death-coded share in the FDA AER plate

Signature read: 13,039 reports place INEFFECTIVE, HOOKS in the upper third of FDA AER volume (#32 of 2,481). Report volume is upper-third scale: 13,039 named reports in the openFDA extract. Death-coded share is lower-third: 38 of 13,039 reports (0.3% of named reports). Nearest volume peer: Depression (±21 reports). Lead species Dog (12,986). Lead co-reported drug Ivermectin + Pyrantel As Pamoate Salt (6,534).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Ivermectin + Pyrantel As Pamoate Salt appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 12,986
Cat 50
Cattle 1
Quail 1
Cockatiel 1

Breeds Most Affected

Retriever - Labrador 1,976
Retriever - Golden 932
Greyhound 874
Crossbred Canine/dog 789
Beagle 589
Shepherd Dog - German 492
Pit Bull 352
Dog (unknown) 319
Boxer (German Boxer) 300
Terrier (unspecified) 274

Associated Drugs

Ivermectin + Pyrantel As Pamoate Salt 6,534
Milbemycin Oxime + Praziquantel 2,404
Milbemycin Oxime + Spinosad 1,019
Lufenuron + Milbemycin Oxime 879
Lufenuron + Milbemycin Oxime + Praziquantel 528
Moxidectin 522
Ivermectin + Pyrantel 310
Imidacloprid + Moxidectin 275
Milbemycin Oxime 273
Milbemycin Oxime, Lufenuron 220
Selamectin 216
Afoxolaner 159
Febantel + Praziquantel + Pyrantel Pamoate 134
Fenbendazole 132
Milbemcyin Oxime, Lufenuron, Praziquantel 114
Fluralaner 110
Milbemycin/Lufenuron Tablets 84
Pyrantel Pamoate 68
Ivermectin + Praziquantel + Pyrantel Pamoate 65
Sarolaner 59

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for INEFFECTIVE, HOOKS, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (13,039 here).

Similar death-coded share

Nearest other reactions by death-coded share (0.3% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for INEFFECTIVE, HOOKS (#32 of 2,481 by report volume); death-coded 0.3%. PlainBreed reaction plate · report volume stamp 13,039 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →