Reaction profile

The FDA adverse-event record for ineffective, hooks

13,040 FDA adverse-event reports reference ineffective, hooks (VeDDRA 99112). See the species, breeds, and drugs most associated with it below.

13,040
reports citing this reaction
0.3%
death-coded share
Dog
most-affected species
Ivermectin + Pyrantel As Pamoate Salt
most-associated drug
Verify with FDA CVM →
13,040
Total Reports
38
Deaths
0.3%
Death Rate

Species Most Affected

Dog 12,987
Cat 50
Cattle 1
Quail 1
Cockatiel 1

Breeds Most Affected

Retriever - Labrador 1,976
Retriever - Golden 932
Greyhound 874
Crossbred Canine/dog 790
Beagle 589
Shepherd Dog - German 492
Pit Bull 352
Dog (unknown) 319
Boxer (German Boxer) 300
Terrier (unspecified) 274

Associated Drugs

Ivermectin + Pyrantel As Pamoate Salt 6,534
Milbemycin Oxime + Praziquantel 2,404
Milbemycin Oxime + Spinosad 1,020
Lufenuron + Milbemycin Oxime 879
Lufenuron + Milbemycin Oxime + Praziquantel 528
Moxidectin 522
Ivermectin + Pyrantel 310
Imidacloprid + Moxidectin 275
Milbemycin Oxime 273
Milbemycin Oxime, Lufenuron 220
Selamectin 216
Afoxolaner 159
Febantel + Praziquantel + Pyrantel Pamoate 134
Fenbendazole 132
Milbemcyin Oxime, Lufenuron, Praziquantel 114
Fluralaner 110
Milbemycin/Lufenuron Tablets 84
Pyrantel Pamoate 68
Ivermectin + Praziquantel + Pyrantel Pamoate 65
Sarolaner 59

INEFFECTIVE, HOOKS Reaction Insights

13,040 reports name INEFFECTIVE, HOOKS; 38 recorded a death outcome (0.3% of reported events, not a population-level mortality rate). VeDDRA code: 99112.

By species: Dog (12,987 reports), Cat (50 reports), Cattle (1 reports). By breed: Retriever - Labrador (1,976), Retriever - Golden (932), Greyhound (874).

Most co-reported drugs: Ivermectin + Pyrantel As Pamoate Salt (6,534 reports), Milbemycin Oxime + Praziquantel (2,404 reports), Milbemycin Oxime + Spinosad (1,020 reports), Lufenuron + Milbemycin Oxime (879 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.