Reaction profile

The FDA adverse-event record for abnormal cytology

2,004 FDA reports name abnormal cytology, a high-volume reaction in the CVM extract (VeDDRA 2588). Plate stamps and neighbourhood peers follow.

#231 of 2,481
by report volume (all reactions)
2,004
reports citing this reaction
11.9%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Abnormal cytology has 2,004 reports now versus 1,902 in that prior snapshot: 102 more (5.4%).

Report change
+102
Death-coded reports
+10
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Abnormal cytology changes

FDA AER · VeDDRA plate

Code 2588 VOL-MID

VOL-MID · DEATH-ELEV · TOP-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 2,004 reports
  • DEATH-ELEV 11.9%
  • TOP-DECILE #231/2481
  • PHOTO-FINISH Cardiac arrest
  • SPECIES-DOG Dog · 1,649
  • DRUG-LEAD Oclacitinib Malea… · 384
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Cardiac arrest (±1 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Abnormal cytology

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Application site prur… · near2009INEFFECTIVE, WHIPS · near2007Abnormal cytology · this rea…2004Cardiac arrest · near2003Hind limb ataxia · near1999Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Abnormal cytology

What the FDA AER plate says about Abnormal cytology

Signature read: 2,004 reports place Abnormal cytology in the upper third of FDA AER volume (#231 of 2,481). Report volume is upper-third scale: 2,004 named reports in the openFDA extract. 238 of 2,004 reports were death-coded (11.9% of named reports, not a population mortality rate). Nearest volume peer: Cardiac arrest (±1 reports). Lead species Dog (1,649). Lead co-reported drug Oclacitinib Maleate (384).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Oclacitinib Maleate appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 1,649
Cat 338
Horse 15
Ferret 1
Lynx 1

Breeds Most Affected

Retriever - Labrador 220
Domestic Shorthair 220
Retriever - Golden 111
Crossbred Canine/dog 88
Shepherd Dog - German 74
Terrier - Bull - American Pit 68
Boxer (German Boxer) 57
Chihuahua 52
Terrier - Yorkshire 38
Terrier (unspecified) 33

Associated Drugs

Oclacitinib Maleate 384
Carprofen 220
Moxidectin 219
Bedinvetmab 199
Gabapentin 185
Prednisone 147
Frunevetmab 141
Maropitant Citrate 140
Anti-Il31 Mab Mcs Lot #1283563 130
Melarsomine Dihydrochloride 124
Cefovecin 112
Fluralaner Chew Tablets 78
Enrofloxacin 66
Trilostane 63
Doxycycline 60
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 59
Afoxolaner 57
Prednisolone 53
Cefpodoxime Proxetil 49
Cephalexin 48

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Abnormal cytology, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (2,004 here).

Similar death-coded share

Nearest other reactions by death-coded share (11.9% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Abnormal cytology (#231 of 2,481 by report volume); death-coded 11.9%. PlainBreed reaction plate · report volume stamp 2,004 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →