Reaction profile

The FDA adverse-event record for ineffective, delayed effect

253 FDA adverse-event reports reference ineffective, delayed effect (VeDDRA 99097). See the species, breeds, and drugs most associated with it below.

253
reports citing this reaction
54.2%
death-coded share
Dog
most-affected species
Pentobarbital, Phenytoin
most-associated drug
Verify with FDA CVM →
253
Total Reports
137
Deaths
54.2%
Death Rate

Species Most Affected

Dog 153
Cat 54
Horse 34
Unknown 4
Cattle 3
Goat 2
Rat 1
Other 1
Other Rodents 1

Breeds Most Affected

Dog (unknown) 44
Domestic Shorthair 19
Cat (unknown) 17
Mixed (Dog) 12
Retriever - Labrador 11
Domestic (unspecified) 9
Crossbred Canine/dog 8
Quarter Horse 8
Horse (unknown) 7
Retriever - Golden 6

Associated Drugs

Pentobarbital, Phenytoin 64
Pentobarbital Sodium + Phenytoin Sodium 34
Pentobarbital Sodium, Phenytoin Sodium 30
Dexmedetomidine Hydrochloride 24
Omeprazole 19
Atipamezole 8
Butorphanol 8
Pentobarbital/Phenytoin Inj 8
Ketamine Hydrochloride 7
Nitenpyram 7
Fluralaner 13.64% 12-Week Chew 7
Afoxolaner 5
Isoflurane 4
Atipamezole Hydrochloride 4
Ketamine 4
Dexmedetomidine 4
Pentobarbital + Phenytoin 3
Selamectin 3
Midazolam 3
Butorphanol Tartrate 2

INEFFECTIVE, DELAYED EFFECT Reaction Insights

253 reports name INEFFECTIVE, DELAYED EFFECT; 137 recorded a death outcome (54.2% of reported events, not a population-level mortality rate). VeDDRA code: 99097.

By species: Dog (153 reports), Cat (54 reports), Horse (34 reports). By breed: Dog (unknown) (44), Domestic Shorthair (19), Cat (unknown) (17).

Most co-reported drugs: Pentobarbital, Phenytoin (64 reports), Pentobarbital Sodium + Phenytoin Sodium (34 reports), Pentobarbital Sodium, Phenytoin Sodium (30 reports), Dexmedetomidine Hydrochloride (24 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.