Reaction profile

The FDA adverse-event record for gastric perforation

438 FDA adverse-event reports reference gastric perforation (VeDDRA 1941). See the species, breeds, and drugs most associated with it below.

438
reports citing this reaction
54.3%
death-coded share
Dog
most-affected species
Deracoxib
most-associated drug
Verify with FDA CVM →
438
Total Reports
238
Deaths
54.3%
Death Rate

Species Most Affected

Dog 415
Cat 13
Horse 5
Pig 3
Cattle 2

Breeds Most Affected

Retriever - Labrador 150
Rottweiler 36
Crossbred Canine/dog 26
Shepherd Dog - German 19
Retriever - Golden 18
Dog (unknown) 13
Boxer (German Boxer) 12
Mastiff 10
Domestic Shorthair 9
Siberian Husky 8

Associated Drugs

Deracoxib 153
Carprofen 121
Firocoxib 69
Meloxicam 51
Tramadol 44
Maropitant Citrate 36
Gabapentin 31
Isoflurane 25
Firocoxib 227 Mg Chewable 24
Anesthetic 16
Propofol 14
Buprenorphine 12
Butorphanol 12
Fentanyl 11
Famotidine 11
Enrofloxacin 11
Oclacitinib Maleate 11
Ketamine 10
Morphine 10
Sucralfate 9

Gastric perforation Reaction Insights

438 reports name Gastric perforation; 238 recorded a death outcome (54.3% of reported events, not a population-level mortality rate). VeDDRA code: 1941.

By species: Dog (415 reports), Cat (13 reports), Horse (5 reports). By breed: Retriever - Labrador (150), Rottweiler (36), Crossbred Canine/dog (26).

Most co-reported drugs: Deracoxib (153 reports), Carprofen (121 reports), Firocoxib (69 reports), Meloxicam (51 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.