Reaction profile

The FDA adverse-event record for gastric perforation

445 FDA reports name gastric perforation, a high-volume reaction in the CVM extract (VeDDRA 1941). Plate stamps and neighbourhood peers follow.

#689 of 2,481
by report volume (all reactions)
445
reports citing this reaction
53.7%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Gastric perforation has 445 reports now versus 442 in that prior snapshot: 3 more (0.7%).

Report change
+3
Death-coded reports
+1
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Gastric perforation changes

FDA AER · VeDDRA plate

Code 1941 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 445 reports
  • DEATH-HOT 53.7%
  • MID-PACK #689/2481
  • PHOTO-FINISH Gastritis
  • SPECIES-DOG Dog · 422
  • DRUG-LEAD Deracoxib · 154
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Gastritis (±2 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Gastric perforation

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Application site grea… · near448Arched back · near448INEFFECTIVE, EUTHANAS… · near448Gastritis · near447Gastric perforation · this r…445Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Gastric perforation

Gastric perforation: high death-coded share in the FDA AER plate

Signature read: 239 death-coded reports is a heavy tail count for Gastric perforation in the CVM extract. Report volume is upper-third scale: 445 named reports in the openFDA extract. Death-coded share is upper-third: 239 of 445 reports (53.7% of named reports). Nearest volume peer: Gastritis (±2 reports). Lead species Dog (422). Lead co-reported drug Deracoxib (154).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 422
Cat 13
Horse 5
Pig 3
Cattle 2

Breeds Most Affected

Retriever - Labrador 151
Rottweiler 36
Crossbred Canine/dog 26
Shepherd Dog - German 20
Retriever - Golden 18
Boxer (German Boxer) 14
Dog (unknown) 13
Mastiff 10
Domestic Shorthair 9
Siberian Husky 8

Associated Drugs

Deracoxib 154
Carprofen 122
Firocoxib 70
Meloxicam 53
Tramadol 44
Maropitant Citrate 37
Gabapentin 33
Isoflurane 26
Firocoxib 227 Mg Chewable 24
Anesthetic 16
Propofol 15
Buprenorphine 13
Butorphanol 13
Fentanyl 11
Famotidine 11
Enrofloxacin 11
Oclacitinib Maleate 11
Ketamine 10
Morphine 10
Acepromazine 9

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Gastric perforation, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (445 here).

Similar death-coded share

Nearest other reactions by death-coded share (53.7% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Gastric perforation (#689 of 2,481 by report volume); death-coded 53.7%. PlainBreed reaction plate · death-coded report count stamp 239 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →