Reaction profile

The FDA adverse-event record for hearing affected

249 FDA adverse-event reports reference hearing affected (VeDDRA 366). See the species, breeds, and drugs most associated with it below.

249
reports citing this reaction
3.2%
death-coded share
Dog
most-affected species
Hydrocortisone Aceponate/Miconazole Nitrate/Gentamicin Sulfate
most-associated drug
Verify with FDA CVM →
249
Total Reports
8
Deaths
3.2%
Death Rate

Species Most Affected

Dog 239
Cat 10

Breeds Most Affected

Retriever - Labrador 20
Terrier - Yorkshire 13
Poodle - Toy 10
Shepherd Dog - German 10
Unknown 10
Shih Tzu 9
Pug 9
Terrier - Jack Russell 9
Mixed (Dog) 9
Retriever - Golden 8

Associated Drugs

Hydrocortisone Aceponate/Miconazole Nitrate/Gentamicin Sulfate 122
Gentamicin Sulfate, Hydrocortisone Aceponate, Miconazole Nitrate 24
Betamethasone Valerate, Usp + Clotrimazole, Usp + Gentamicin Sulfate, Usp 13
Carprofen 9
Betamethasone + Florfenicol + Terbinafine 9
Miconazole + Polymyxin B + Prednisolone 8
Enrofloxacin + Silver Sulfadiazine 7
Milbemycin Oxime + Spinosad 7
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 7
Enrofloxacin 4
Prednisone 4
Cefovecin 4
Ear Cleaner (Unknown) 4
Grapiprant 4
Oclacitinib Maleate 4
Famotidine 3
Ear Cleaner 3
Gabapentin 3
Trazadone 3
Pyrantel Pamoate;Sarolaner 3

Hearing affected Reaction Insights

249 reports name Hearing affected; 8 recorded a death outcome (3.2% of reported events, not a population-level mortality rate). VeDDRA code: 366.

By species: Dog (239 reports), Cat (10 reports). By breed: Retriever - Labrador (20), Terrier - Yorkshire (13), Poodle - Toy (10).

Most co-reported drugs: Hydrocortisone Aceponate/Miconazole Nitrate/Gentamicin Sulfate (122 reports), Gentamicin Sulfate, Hydrocortisone Aceponate, Miconazole Nitrate (24 reports), Betamethasone Valerate, Usp + Clotrimazole, Usp + Gentamicin Sulfate, Usp (13 reports), Carprofen (9 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.