Reaction profile

The FDA adverse-event record for drug dispensing error

253 FDA adverse-event reports reference drug dispensing error (VeDDRA 99822). See the species, breeds, and drugs most associated with it below.

253
reports citing this reaction
8.3%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
253
Total Reports
21
Deaths
8.3%
Death Rate

Species Most Affected

Dog 188
Cat 30
Unknown 13
Cattle 9
Chicken 3
Human 3
Pig 2
Goat 1
Sheep 1
Turkey 1

Breeds Most Affected

Unknown 21
Terrier - Yorkshire 19
Chihuahua 16
Shih Tzu 13
Dog (unknown) 11
Domestic Shorthair 10
Domestic (unspecified) 9
Spaniel - King Charles Cavalier 7
Schnauzer (unspecified) 7
Maltese 6

Associated Drugs

Milbemycin Oxime + Spinosad 74
Spinosad 34
Trilostane 13
Monensin Sodium 13
Oclacitinib Maleate 13
Carprofen 12
Levothyroxine Sodium 12
Fluralaner 13.64% 12-Week Chew 12
Human Insulin 9
Clomipramine 7
Ivermectin 6
Fluralaner Chew Tablets 6
Imidacloprid + Moxidectin 5
Clomipramine Hydrochloride 5
Lufenuron + Milbemycin Oxime 5
Selamectin 4
Firocoxib 4
Ivermectin + Pyrantel 3
Gabapentin 3
Grapiprant 3

Drug dispensing error Reaction Insights

253 reports name Drug dispensing error; 21 recorded a death outcome (8.3% of reported events, not a population-level mortality rate). VeDDRA code: 99822.

By species: Dog (188 reports), Cat (30 reports), Unknown (13 reports). By breed: Unknown (21), Terrier - Yorkshire (19), Chihuahua (16).

Most co-reported drugs: Milbemycin Oxime + Spinosad (74 reports), Spinosad (34 reports), Trilostane (13 reports), Monensin Sodium (13 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.