INEFFECTIVE, ANESTHESIA

Verify with FDA CVM →

VeDDRA Code: 99082

1,027 adverse event reports referencing this reaction

1,027
Total Reports
78
Deaths
760.0%
Death Rate

Species Most Affected

Dog 520
Cat 244
Horse 144
Other 44
Mouse 16
Rat 14
Monkey 6
Other Rodents 5
Other Mammals 5
Rabbit 4

Breeds Most Affected

Dog (unknown) 204
Unknown 130
Cat (unknown) 94
Domestic (unspecified) 55
Horse (unknown) 50
Crossbred Canine/dog 46
Mixed (Dog) 31
Quarter Horse 27
Domestic Shorthair 27
Cat (other) 24

Associated Drugs

Ketamine Hydrochloride 340
Isoflurane 248
Propofol 180
Tiletamine Hcl; Zolazapam Hcl 94
Tiletamine, Zolazepam 51
Sevoflurane 45
Ketamine Hcl 38
Xylazine 36
Dexmedetomidine Hydrochloride 27
Butorphanol 26
Acepromazine 21
Xylazine Hcl 19
Acepromazine Maleate 18
Midazolam 18
Diazepam 13
Ketamine 13
Hydromorphone 12
Butorphanol Tartrate 12
Buprenorphine 12
Xylazine Hydrochloride 9

Data Summary

Metric Value
Total reports referencing reaction 1,027
Reports with fatal outcome 78
Case-fatality rate (reported events) 760.0%
Species observed 10
Breeds observed 20
Drugs associated with reaction 20

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER); reaction term coded under VeDDRA 99082.

INEFFECTIVE, ANESTHESIA Reaction Insights

The FDA Center for Veterinary Medicine database currently lists 1,027 adverse event reports that reference INEFFECTIVE, ANESTHESIA as a reaction term, including 78 reports with a death outcome — a 760.0% case-fatality figure calculated across only those events where this reaction was coded. The reaction is indexed in the openFDA system under VeDDRA code 99082, the standardized veterinary dictionary used to normalize clinical signs across submitters. Because reports are voluntary and often describe multiple concurrent signs per animal, the volume here reflects reporting intensity rather than true incidence in the broader pet population.

INEFFECTIVE, ANESTHESIA appears most frequently in reports for Dog (520 reports), Cat (244 reports), Horse (144 reports) — with Dog dominating at 520 entries. Within those species, the breeds most often named alongside this reaction are Dog (unknown) (204), Unknown (130), Cat (unknown) (94). These distributions are influenced both by underlying breed popularity and by how veterinarians and owners code a given clinical sign, so they should be interpreted as a reporting fingerprint rather than a pure susceptibility ranking.

The drugs most commonly co-reported with INEFFECTIVE, ANESTHESIA are Ketamine Hydrochloride (340 reports), Isoflurane (248 reports), Propofol (180 reports), Tiletamine Hcl; Zolazapam Hcl (94 reports), with Ketamine Hydrochloride appearing alongside this reaction in 340 submissions. Co-reporting does not establish that any specific product caused the reaction — FDA CVM data captures temporal association only. The value of these aggregates is in flagging which therapeutic classes appear repeatedly alongside a given clinical sign, so owners and veterinarians can ask targeted questions about medications currently in use.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial