Reaction profile

The FDA adverse-event record for ineffective, anesthesia

1,027 FDA adverse-event reports reference ineffective, anesthesia (VeDDRA 99082). See the species, breeds, and drugs most associated with it below.

1,027
reports citing this reaction
7.6%
death-coded share
Dog
most-affected species
Ketamine Hydrochloride
most-associated drug
Verify with FDA CVM →
1,027
Total Reports
78
Deaths
7.6%
Death Rate

Species Most Affected

Dog 520
Cat 244
Horse 144
Other 44
Mouse 16
Rat 14
Monkey 6
Other Rodents 5
Other Mammals 5
Rabbit 4

Breeds Most Affected

Dog (unknown) 204
Unknown 130
Cat (unknown) 94
Domestic (unspecified) 55
Horse (unknown) 50
Crossbred Canine/dog 46
Mixed (Dog) 31
Quarter Horse 27
Domestic Shorthair 27
Cat (other) 24

Associated Drugs

Ketamine Hydrochloride 340
Isoflurane 248
Propofol 180
Tiletamine Hcl; Zolazapam Hcl 94
Tiletamine, Zolazepam 51
Sevoflurane 45
Ketamine Hcl 38
Xylazine 36
Dexmedetomidine Hydrochloride 27
Butorphanol 26
Acepromazine 21
Xylazine Hcl 19
Acepromazine Maleate 18
Midazolam 18
Diazepam 13
Ketamine 13
Hydromorphone 12
Butorphanol Tartrate 12
Buprenorphine 12
Xylazine Hydrochloride 9

INEFFECTIVE, ANESTHESIA Reaction Insights

1,027 reports name INEFFECTIVE, ANESTHESIA; 78 recorded a death outcome (7.6% of reported events, not a population-level mortality rate). VeDDRA code: 99082.

By species: Dog (520 reports), Cat (244 reports), Horse (144 reports). By breed: Dog (unknown) (204), Unknown (130), Cat (unknown) (94).

Most co-reported drugs: Ketamine Hydrochloride (340 reports), Isoflurane (248 reports), Propofol (180 reports), Tiletamine Hcl; Zolazapam Hcl (94 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.