Reaction profile

The FDA adverse-event record for ineffective, anesthesia

1,034 FDA reports name ineffective, anesthesia, a high-volume reaction in the CVM extract (VeDDRA 99082). Plate stamps and neighbourhood peers follow.

#386 of 2,481
by report volume (all reactions)
1,034
reports citing this reaction
7.6%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. INEFFECTIVE, ANESTHESIA has 1,034 reports now versus 1,032 in that prior snapshot: 2 more (0.2%).

Report change
+2
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to INEFFECTIVE, ANESTHESIA changes

FDA AER · VeDDRA plate

Code 99082 VOL-MID

VOL-MID · DEATH-PAR · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 1,034 reports
  • DEATH-PAR 7.6%
  • UPPER-Q #386/2481
  • PHOTO-FINISH General hair loss
  • SPECIES-DOG Dog · 525
  • DRUG-LEAD Ketamine Hydrochl… · 340
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: General hair loss (±2 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around INEFFECTIVE, ANESTHESIA

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Partial deafness · near1041Decreased haematocrit · near1039INEFFECTIVE, CUSHINGS · near1037INEFFECTIVE, ANESTHES… · thi…1034General hair loss · near1032Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around INEFFECTIVE, ANESTHESIA

INEFFECTIVE, ANESTHESIA: low death-coded share in the FDA AER plate

Signature read: 1,034 reports place INEFFECTIVE, ANESTHESIA in the upper third of FDA AER volume (#386 of 2,481). Report volume is upper-third scale: 1,034 named reports in the openFDA extract. Death-coded share is lower-third: 79 of 1,034 reports (7.6% of named reports). Nearest volume peer: General hair loss (±2 reports). Lead species Dog (525). Lead co-reported drug Ketamine Hydrochloride (340).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Ketamine Hydrochloride appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 525
Cat 244
Horse 144
Other 44
Mouse 16
Rat 14
Other Mammals 7
Monkey 6
Other Rodents 5
Rabbit 4

Breeds Most Affected

Dog (unknown) 204
Unknown 132
Cat (unknown) 94
Domestic (unspecified) 55
Horse (unknown) 50
Crossbred Canine/dog 46
Mixed (Dog) 33
Quarter Horse 27
Domestic Shorthair 27
Cat (other) 24

Associated Drugs

Ketamine Hydrochloride 340
Isoflurane 248
Propofol 180
Tiletamine Hcl; Zolazapam Hcl 94
Tiletamine, Zolazepam 51
Sevoflurane 48
Ketamine Hcl 38
Xylazine 36
Dexmedetomidine Hydrochloride 27
Butorphanol 26
Acepromazine 21
Xylazine Hcl 19
Acepromazine Maleate 18
Midazolam 18
Diazepam 13
Ketamine 13
Hydromorphone 12
Butorphanol Tartrate 12
Buprenorphine 12
Xylazine Hydrochloride 9

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for INEFFECTIVE, ANESTHESIA, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (1,034 here).

Similar death-coded share

Nearest other reactions by death-coded share (7.6% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for INEFFECTIVE, ANESTHESIA (#386 of 2,481 by report volume); death-coded 7.6%. PlainBreed reaction plate · report volume stamp 1,034 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →