Reaction profile

The FDA adverse-event record for general hair loss

1,011 FDA adverse-event reports reference general hair loss (VeDDRA 1490). See the species, breeds, and drugs most associated with it below.

1,011
reports citing this reaction
3.2%
death-coded share
Dog
most-affected species
Trilostane
most-associated drug
Verify with FDA CVM →
1,011
Total Reports
32
Deaths
3.2%
Death Rate

Species Most Affected

Dog 670
Cat 261
Cattle 63
Horse 5
Human 4
Ferret 4
Goat 2
Unknown 1
Sheep 1

Breeds Most Affected

Domestic Shorthair 172
Retriever - Labrador 64
Crossbred Canine/dog 60
Chihuahua 36
Shepherd Dog - German 33
Retriever - Golden 32
Pit Bull 22
Aberdeen Angus 22
Domestic Longhair 22
Shih Tzu 18

Associated Drugs

Trilostane 134
Milbemycin Oxime + Spinosad 116
Fluralaner Chew Tablets 86
Fluralaner Spot-On Solution 86
Selamectin 55
Afoxolaner 52
Fluralaner 13.64% 12-Week Chew 49
Spinosad 35
Selamectin;Sarolaner 35
Nitenpyram 31
Portech App Gun 65 Ml Ivomec/Eprinex 30
Imidacloprid + Moxidectin 28
Oclacitinib Maleate 28
Ivermectin 0.5% Pour-On Topical Solution 26
Gabapentin 24
Frunevetmab 24
Carprofen 23
Pyrantel Pamoate;Sarolaner 22
Fluralaner/Moxidectin Spot-On 21
Prednisone 19

General hair loss Reaction Insights

1,011 reports name General hair loss; 32 recorded a death outcome (3.2% of reported events, not a population-level mortality rate). VeDDRA code: 1490.

By species: Dog (670 reports), Cat (261 reports), Cattle (63 reports). By breed: Domestic Shorthair (172), Retriever - Labrador (64), Crossbred Canine/dog (60).

Most co-reported drugs: Trilostane (134 reports), Milbemycin Oxime + Spinosad (116 reports), Fluralaner Chew Tablets (86 reports), Fluralaner Spot-On Solution (86 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.