Reaction profile

The FDA adverse-event record for general hair loss

1,032 FDA reports name general hair loss, a high-volume reaction in the CVM extract (VeDDRA 1490). Plate stamps and neighbourhood peers follow.

#387 of 2,481
by report volume (all reactions)
1,032
reports citing this reaction
3.2%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. General hair loss has 1,032 reports now versus 1,027 in that prior snapshot: 5 more (0.5%).

Report change
+5
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to General hair loss changes

FDA AER · VeDDRA plate

Code 1490 VOL-MID

VOL-MID · DEATH-LOW · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 1,032 reports
  • DEATH-LOW 3.2%
  • UPPER-Q #387/2481
  • PHOTO-FINISH INEFFECTIVE, ANESTHES…
  • SPECIES-DOG Dog · 679
  • DRUG-LEAD Trilostane · 135
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: INEFFECTIVE, ANESTHESIA (±2 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around General hair loss

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Partial deafness · near1041Decreased haematocrit · near1039INEFFECTIVE, CUSHINGS · near1037INEFFECTIVE, ANESTHES… · near1034General hair loss · this rea…1032Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around General hair loss

General hair loss: low death-coded share in the FDA AER plate

Signature read: 1,032 reports place General hair loss in the upper third of FDA AER volume (#387 of 2,481). Report volume is upper-third scale: 1,032 named reports in the openFDA extract. Death-coded share is lower-third: 33 of 1,032 reports (3.2% of named reports). Nearest volume peer: INEFFECTIVE, ANESTHESIA (±2 reports). Lead species Dog (679). Lead co-reported drug Trilostane (135).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Trilostane appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 679
Cat 273
Cattle 63
Horse 5
Human 4
Ferret 4
Goat 2
Unknown 1
Sheep 1

Breeds Most Affected

Domestic Shorthair 177
Retriever - Labrador 65
Crossbred Canine/dog 61
Chihuahua 37
Shepherd Dog - German 33
Retriever - Golden 32
Domestic Longhair 24
Pit Bull 22
Aberdeen Angus 22
Shih Tzu 20

Associated Drugs

Trilostane 135
Milbemycin Oxime + Spinosad 116
Fluralaner Chew Tablets 86
Fluralaner Spot-On Solution 86
Selamectin 56
Afoxolaner 54
Fluralaner 13.64% 12-Week Chew 49
Selamectin;Sarolaner 38
Spinosad 35
Nitenpyram 31
Oclacitinib Maleate 30
Portech App Gun 65 Ml Ivomec/Eprinex 30
Imidacloprid + Moxidectin 28
Ivermectin 0.5% Pour-On Topical Solution 26
Fluralaner/Moxidectin Spot-On 25
Frunevetmab 25
Gabapentin 24
Carprofen 23
Pyrantel Pamoate;Sarolaner 22
Prednisone 19

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for General hair loss, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (1,032 here).

Similar death-coded share

Nearest other reactions by death-coded share (3.2% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for General hair loss (#387 of 2,481 by report volume); death-coded 3.2%. PlainBreed reaction plate · report volume stamp 1,032 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →