Reaction profile

The FDA adverse-event record for basophilia

355 FDA adverse-event reports reference basophilia (VeDDRA 2219). See the species, breeds, and drugs most associated with it below.

355
reports citing this reaction
27.0%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
355
Total Reports
96
Deaths
27.0%
Death Rate

Species Most Affected

Dog 286
Cat 63
Horse 5
Rabbit 1

Breeds Most Affected

Domestic Shorthair 36
Retriever - Labrador 33
Shepherd Dog - German 20
Crossbred Canine/dog 19
Retriever - Golden 16
Boxer (German Boxer) 14
Shih Tzu 12
Chihuahua 9
Terrier - Yorkshire 9
Domestic Longhair 9

Associated Drugs

Milbemycin Oxime + Spinosad 37
Afoxolaner 34
Maropitant Citrate 30
Carprofen 28
Ivermectin + Pyrantel As Pamoate Salt 23
Gabapentin 22
Fluralaner Chew Tablets 20
Milbemycin Oxime + Praziquantel 19
Prednisone 18
Metronidazole 18
Oclacitinib Maleate 15
Polysulfated Glycosaminoglycan 15
Doxycycline 14
Grapiprant 14
Spinosad 13
Bedinvetmab 13
Meloxicam 11
Enrofloxacin 11
Selamectin 10
Cefovecin 10

Basophilia Reaction Insights

355 reports name Basophilia; 96 recorded a death outcome (27.0% of reported events, not a population-level mortality rate). VeDDRA code: 2219.

By species: Dog (286 reports), Cat (63 reports), Horse (5 reports). By breed: Domestic Shorthair (36), Retriever - Labrador (33), Shepherd Dog - German (20).

Most co-reported drugs: Milbemycin Oxime + Spinosad (37 reports), Afoxolaner (34 reports), Maropitant Citrate (30 reports), Carprofen (28 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.