Reaction profile

The FDA adverse-event record for indigestion

56 FDA reports name indigestion, a lower-volume reaction in the CVM extract (VeDDRA 1536). Plate stamps and neighbourhood peers follow.

#1683 of 2,481
by report volume (all reactions)
56
reports citing this reaction
8.9%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Indigestion has 56 reports now versus 54 in that prior snapshot: 2 more (3.7%).

Report change
+2
Death-coded reports
+0
Death-coded share
−0.3 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Indigestion changes

FDA AER · VeDDRA plate

Code 1536 VOL-LOW

VOL-LOW · DEATH-PAR · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 56 reports
  • DEATH-PAR 8.9%
  • MID-PACK #1683/2481
  • PHOTO-FINISH Abdominal oedema
  • SPECIES-DOG Dog · 44
  • DRUG-LEAD Milbemycin Oxime… · 6
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Abdominal oedema (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Lower-volume neighbourhood around Indigestion

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Abdominal oedema · near56Abnormal oestrus NOS · near56High leg gait · near56Indigestion · this reaction56Pinnal haemorrhage · near56Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Indigestion

What the FDA AER plate says about Indigestion

Signature read: 5 death-coded reports is a thin tail count for Indigestion in the CVM extract. Report volume is lower-third scale: 56 named reports in the openFDA extract. 5 of 56 reports were death-coded (8.9% of named reports, not a population mortality rate). Nearest volume peer: Abdominal oedema (±0 reports). Lead species Dog (44). Lead co-reported drug Milbemycin Oxime + Praziquantel (6).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Praziquantel appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 44
Cattle 5
Human 4
Other 2
Cat 1

Breeds Most Affected

Unknown 10
Dog (unknown) 5
Retriever - Golden 5
Shepherd Dog - German 4
Holstein-Friesian also known as Holstein 4
Retriever - Labrador 2
Collie - Border 2
Terrier - Rat 2
Schnauzer (unspecified) 1
Pointing Dog - German (unspecified) 1

Associated Drugs

Milbemycin Oxime + Praziquantel 6
Milbemycin Oxime + Spinosad 5
Monensin Sodium 5
Ivermectin 5
Neomycin Sulfate, Usp + Nystatin, Usp + Thiostrepton, [Usp] + Triamcinolone Acetonide, Usp 4
Lotilaner 4
Afoxolaner 3
Imidacloprid + Permethrin 3
Pyrantel Pamoate;Sarolaner 3
Maropitant Citrate 3
Metronidazole 3
Ivermectin + Pyrantel As Pamoate Salt 2
Neomycin + Nystatin + Thiostrepton + Triamcinolone 2
Clotrimazole + Gentamicin + Mometasone 2
Grapiprant 2
Gabapentin 2
Bedinvetmab 2
Enrofloxacin 2
Famotidine 2
Diet Food 2

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Indigestion, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (56 here).

Similar death-coded share

Nearest other reactions by death-coded share (8.9% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Indigestion (#1683 of 2,481 by report volume); death-coded 8.9%. PlainBreed reaction plate · death-coded report count stamp 5 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →