Reaction profile

The FDA adverse-event record for indigestion

50 FDA adverse-event reports reference indigestion (VeDDRA 1536). See the species, breeds, and drugs most associated with it below.

50
reports citing this reaction
10.0%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
50
Total Reports
5
Deaths
10.0%
Death Rate

Species Most Affected

Dog 39
Cattle 5
Human 4
Other 2

Breeds Most Affected

Unknown 10
Dog (unknown) 4
Retriever - Golden 4
Shepherd Dog - German 4
Holstein-Friesian also known as Holstein 4
Retriever - Labrador 2
Collie - Border 2
Schnauzer (unspecified) 1
Pointing Dog - German (unspecified) 1
Jersey 1

Associated Drugs

Milbemycin Oxime + Spinosad 5
Monensin Sodium 5
Milbemycin Oxime + Praziquantel 5
Neomycin Sulfate, Usp + Nystatin, Usp + Thiostrepton, [Usp] + Triamcinolone Acetonide, Usp 4
Afoxolaner 3
Ivermectin 3
Imidacloprid + Permethrin 3
Pyrantel Pamoate;Sarolaner 3
Ivermectin + Pyrantel As Pamoate Salt 2
Neomycin + Nystatin + Thiostrepton + Triamcinolone 2
Clotrimazole + Gentamicin + Mometasone 2
Lotilaner 2
Grapiprant 2
Bedinvetmab 2
Nitenpyram 1
Cetirizine 1
Paroxetine 1
Ciprofloxacin 1
Bupropion 1
Spinosad 1

Indigestion Reaction Insights

50 reports name Indigestion; 5 recorded a death outcome (10.0% of reported events, not a population-level mortality rate). VeDDRA code: 1536.

By species: Dog (39 reports), Cattle (5 reports), Human (4 reports). By breed: Unknown (10), Dog (unknown) (4), Retriever - Golden (4).

Most co-reported drugs: Milbemycin Oxime + Spinosad (5 reports), Monensin Sodium (5 reports), Milbemycin Oxime + Praziquantel (5 reports), Neomycin Sulfate, Usp + Nystatin, Usp + Thiostrepton, [Usp] + Triamcinolone Acetonide, Usp (4 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.