Reaction profile

The FDA adverse-event record for joint pain nos

180 FDA adverse-event reports reference joint pain nos (VeDDRA 586). See the species, breeds, and drugs most associated with it below.

180
reports citing this reaction
9.4%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
180
Total Reports
17
Deaths
9.4%
Death Rate

Species Most Affected

Dog 156
Cat 11
Human 7
Horse 5
Pig 1

Breeds Most Affected

Retriever - Labrador 18
Shepherd Dog - German 15
Unknown 7
Domestic Shorthair 7
Crossbred Canine/dog 7
Boxer (German Boxer) 6
Retriever - Golden 5
Rottweiler 4
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 4
Terrier (unspecified) 4

Associated Drugs

Milbemycin Oxime + Spinosad 35
Trilostane 19
Bedinvetmab 17
Carprofen 16
Gabapentin 16
Enrofloxacin 13
Tramadol 11
Maropitant Citrate 10
Oclacitinib Maleate 10
Fluralaner Chew Tablets 10
Afoxolaner 9
Spinosad 8
Meloxicam 7
Polysulfated Glycosaminoglycan 7
Deracoxib 6
Prednisone 6
Milbemycin Oxime + Praziquantel 6
Famotidine 5
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 5
Amantadine 5

Joint pain NOS Reaction Insights

180 reports name Joint pain NOS; 17 recorded a death outcome (9.4% of reported events, not a population-level mortality rate). VeDDRA code: 586.

By species: Dog (156 reports), Cat (11 reports), Human (7 reports). By breed: Retriever - Labrador (18), Shepherd Dog - German (15), Unknown (7).

Most co-reported drugs: Milbemycin Oxime + Spinosad (35 reports), Trilostane (19 reports), Bedinvetmab (17 reports), Carprofen (16 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.