Reaction profile

The FDA adverse-event record for increased percentage reticulocytes

894 FDA adverse-event reports reference increased percentage reticulocytes (VeDDRA 2213). See the species, breeds, and drugs most associated with it below.

894
reports citing this reaction
26.4%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
894
Total Reports
236
Deaths
26.4%
Death Rate

Species Most Affected

Dog 796
Cat 98

Breeds Most Affected

Retriever - Labrador 76
Crossbred Canine/dog 67
Domestic Shorthair 60
Chihuahua 40
Retriever - Golden 37
Shih Tzu 29
Shepherd Dog - German 28
Terrier - Yorkshire 24
Boxer (German Boxer) 20
Maltese 19

Associated Drugs

Carprofen 115
Maropitant Citrate 84
Afoxolaner 72
Trilostane 67
Oclacitinib Maleate 65
Prednisone 60
Fluralaner Chew Tablets 50
Ivermectin + Pyrantel As Pamoate Salt 49
Milbemycin Oxime + Spinosad 46
Moxidectin 46
Gabapentin 44
Doxycycline 40
Bedinvetmab 37
Enrofloxacin 36
Fluralaner 13.64% 12-Week Chew 36
Rabies Vaccine 33
Cyclosporine 32
Grapiprant 30
Deracoxib 28
Metronidazole 28

Increased percentage reticulocytes Reaction Insights

894 reports name Increased percentage reticulocytes; 236 recorded a death outcome (26.4% of reported events, not a population-level mortality rate). VeDDRA code: 2213.

By species: Dog (796 reports), Cat (98 reports). By breed: Retriever - Labrador (76), Crossbred Canine/dog (67), Domestic Shorthair (60).

Most co-reported drugs: Carprofen (115 reports), Maropitant Citrate (84 reports), Afoxolaner (72 reports), Trilostane (67 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.