Reaction profile

The FDA adverse-event record for jaundice

980 FDA reports name jaundice, a high-volume reaction in the CVM extract (VeDDRA 501). Plate stamps and neighbourhood peers follow.

#400 of 2,481
by report volume (all reactions)
980
reports citing this reaction
42.1%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Jaundice has 980 reports now versus 959 in that prior snapshot: 21 more (2.2%).

Report change
+21
Death-coded reports
+6
Death-coded share
−0.3 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Jaundice changes

FDA AER · VeDDRA plate

Code 501 VOL-MID

VOL-MID · DEATH-HOT · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 980 reports
  • DEATH-HOT 42.1%
  • UPPER-Q #400/2481
  • PHOTO-FINISH Abnormal movement NOS
  • SPECIES-DOG Dog · 728
  • DRUG-LEAD Carprofen · 321
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Abnormal movement NOS (±2 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Jaundice

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Lack of efficacy (tap… · near990Stopper, abnormal · near984Increased percentage… · near983Jaundice · this reaction980Abnormal movement NOS · near978Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Jaundice

Jaundice: high death-coded share in the FDA AER plate

Signature read: 413 death-coded reports is a heavy tail count for Jaundice in the CVM extract. Report volume is upper-third scale: 980 named reports in the openFDA extract. Death-coded share is upper-third: 413 of 980 reports (42.1% of named reports). Nearest volume peer: Abnormal movement NOS (±2 reports). Lead species Dog (728). Lead co-reported drug Carprofen (321).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 728
Cat 236
Human 5
Cattle 4
Horse 4
Other Reptiles 1
Mule 1
Goat 1

Breeds Most Affected

Retriever - Labrador 199
Domestic Shorthair 155
Crossbred Canine/dog 52
Domestic Longhair 23
Pit Bull 23
Shepherd Dog - German 22
Shepherd Dog - Australian 19
Retriever - Golden 18
Chihuahua 18
Shih Tzu 16

Associated Drugs

Carprofen 321
Maropitant Citrate 146
Famotidine 49
Moxidectin 47
Milbemycin Oxime + Spinosad 45
Metronidazole 41
Tramadol 39
Sam-E, Silybin, Vitamin E, Zinc 39
Gabapentin 37
Cefovecin 37
Afoxolaner 34
Prednisone 33
Enrofloxacin 32
Oclacitinib Maleate 32
Isoflurane 29
Fluralaner Chew Tablets 29
Itraconazole 28
Spinosad 27
Sucralfate 27
Doxycycline 25

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Jaundice, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (42.1% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Jaundice (#400 of 2,481 by report volume); death-coded 42.1%. PlainBreed reaction plate · death-coded report count stamp 413 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →