Reaction profile

The FDA adverse-event record for cough

6,845 FDA reports name cough, a high-volume reaction in the CVM extract (VeDDRA 884). Plate stamps and neighbourhood peers follow.

#75 of 2,481
by report volume (all reactions)
6,845
reports citing this reaction
13.9%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Cough has 6,845 reports now versus 6,757 in that prior snapshot: 88 more (1.3%).

Report change
+88
Death-coded reports
+11
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Cough changes

FDA AER · VeDDRA plate

Code 884 VOL-HIGH

VOL-HIGH · DEATH-ELEV · TOP-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-HIGH 6,845 reports
  • DEATH-ELEV 13.9%
  • TOP-DECILE #75/2481
  • PHOTO-FINISH Weakness
  • SPECIES-DOG Dog · 6,109
  • DRUG-LEAD Milbemycin Oxime… · 970
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Weakness (±9 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Cough

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Lack of efficacy (end… · near7126Underfilling, Package · near6969Application site alop… · near6932Weakness · near6854Cough · this reaction6845Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Cough

What the FDA AER plate says about Cough

Signature read: 951 death-coded reports is a heavy tail count for Cough in the CVM extract. Report volume is upper-third scale: 6,845 named reports in the openFDA extract. 951 of 6,845 reports were death-coded (13.9% of named reports, not a population mortality rate). Nearest volume peer: Weakness (±9 reports). Lead species Dog (6,109). Lead co-reported drug Milbemycin Oxime + Spinosad (970).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 6,109
Cat 496
Cattle 83
Human 79
Horse 50
Pig 16
Donkey 3
Sheep 2
Other Canids 1
Ferret 1

Breeds Most Affected

Retriever - Labrador 633
Crossbred Canine/dog 531
Chihuahua 387
Domestic Shorthair 257
Retriever - Golden 217
Shih Tzu 200
Dog (unknown) 200
Terrier - Yorkshire 197
Boxer (German Boxer) 170
Beagle 166

Associated Drugs

Milbemycin Oxime + Spinosad 970
Ivermectin + Pyrantel As Pamoate Salt 399
Pimobendan 352
Milbemycin Oxime + Praziquantel 330
Oclacitinib Maleate 317
Moxidectin 310
Afoxolaner 306
Bedinvetmab 297
Spinosad 288
Melarsomine Dihydrochloride 286
Imidacloprid + Moxidectin 277
Carprofen 271
Maropitant Citrate 247
Doxycycline 228
Trilostane 217
Melarsomine Dihydrochloride Injection 216
Prednisone 182
Fluralaner Chew Tablets 179
Pyrantel Pamoate;Sarolaner 170
Gabapentin 163

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Cough, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Cough (#75 of 2,481 by report volume); death-coded 13.9%. PlainBreed reaction plate · death-coded report count stamp 951 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →