Reaction profile

The FDA adverse-event record for cough

6,628 FDA adverse-event reports reference cough (VeDDRA 884). See the species, breeds, and drugs most associated with it below.

6,628
reports citing this reaction
13.8%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
6,628
Total Reports
914
Deaths
13.8%
Death Rate

Species Most Affected

Dog 5,915
Cat 477
Cattle 81
Human 78
Horse 49
Pig 16
Donkey 3
Sheep 2
Other Canids 1
Ferret 1

Breeds Most Affected

Retriever - Labrador 615
Crossbred Canine/dog 517
Chihuahua 376
Domestic Shorthair 245
Retriever - Golden 207
Terrier - Yorkshire 194
Shih Tzu 193
Dog (unknown) 192
Boxer (German Boxer) 166
Beagle 162

Associated Drugs

Milbemycin Oxime + Spinosad 965
Ivermectin + Pyrantel As Pamoate Salt 391
Pimobendan 334
Milbemycin Oxime + Praziquantel 314
Moxidectin 303
Afoxolaner 302
Oclacitinib Maleate 301
Spinosad 288
Melarsomine Dihydrochloride 276
Imidacloprid + Moxidectin 274
Bedinvetmab 262
Carprofen 249
Melarsomine Dihydrochloride Injection 216
Maropitant Citrate 212
Trilostane 211
Doxycycline 211
Fluralaner Chew Tablets 179
Prednisone 170
Pyrantel Pamoate;Sarolaner 161
Gabapentin 147

Cough Reaction Insights

6,628 reports name Cough; 914 recorded a death outcome (13.8% of reported events, not a population-level mortality rate). VeDDRA code: 884.

By species: Dog (5,915 reports), Cat (477 reports), Cattle (81 reports). By breed: Retriever - Labrador (615), Crossbred Canine/dog (517), Chihuahua (376).

Most co-reported drugs: Milbemycin Oxime + Spinosad (965 reports), Ivermectin + Pyrantel As Pamoate Salt (391 reports), Pimobendan (334 reports), Milbemycin Oxime + Praziquantel (314 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.