Reaction profile

The FDA adverse-event record for drinking a lot

2,033 FDA adverse-event reports reference drinking a lot (VeDDRA 545). See the species, breeds, and drugs most associated with it below.

2,033
reports citing this reaction
14.0%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
2,033
Total Reports
284
Deaths
14.0%
Death Rate

Species Most Affected

Dog 1,808
Cat 215
Horse 4
Unknown 1
Cattle 1
Pig 1
Other 1
Human 1
Goat 1

Breeds Most Affected

Retriever - Labrador 215
Domestic Shorthair 124
Crossbred Canine/dog 110
Shepherd Dog - German 91
Retriever - Golden 68
Chihuahua 65
Dog (unknown) 60
Boxer (German Boxer) 56
Shih Tzu 53
Terrier - Yorkshire 52

Associated Drugs

Milbemycin Oxime + Spinosad 257
Bedinvetmab 138
Carprofen 133
Spinosad 127
Fluralaner Chew Tablets 118
Afoxolaner 113
Pyrantel Pamoate;Sarolaner 111
Gabapentin 88
Oclacitinib Maleate 79
Milbemycin Oxime + Praziquantel 79
Ivermectin + Pyrantel As Pamoate Salt 74
Fluralaner 13.64% 12-Week Chew 71
Grapiprant 70
Prednisone 63
Maropitant Citrate 55
Lotilaner 55
Trilostane 50
Nitenpyram 50
Deracoxib 38
Bexagliflozin 38

Drinking a lot Reaction Insights

2,033 reports name Drinking a lot; 284 recorded a death outcome (14.0% of reported events, not a population-level mortality rate). VeDDRA code: 545.

By species: Dog (1,808 reports), Cat (215 reports), Horse (4 reports). By breed: Retriever - Labrador (215), Domestic Shorthair (124), Crossbred Canine/dog (110).

Most co-reported drugs: Milbemycin Oxime + Spinosad (257 reports), Bedinvetmab (138 reports), Carprofen (133 reports), Spinosad (127 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.