Reaction profile

The FDA adverse-event record for gall bladder & bile duct disorder nos

837 FDA adverse-event reports reference gall bladder & bile duct disorder nos (VeDDRA 480). See the species, breeds, and drugs most associated with it below.

837
reports citing this reaction
33.5%
death-coded share
Dog
most-affected species
Trilostane
most-associated drug
Verify with FDA CVM →
837
Total Reports
280
Deaths
33.5%
Death Rate

Species Most Affected

Dog 786
Cat 48
Cattle 1
Human 1
Unknown 1

Breeds Most Affected

Retriever - Labrador 82
Crossbred Canine/dog 62
Chihuahua 35
Shih Tzu 32
Terrier - Yorkshire 27
Maltese 23
Domestic Shorthair 23
Beagle 22
Schnauzer - Miniature 21
Shepherd Dog - German 19

Associated Drugs

Trilostane 187
Carprofen 128
Maropitant Citrate 121
Milbemycin Oxime + Spinosad 84
Metronidazole 40
Moxidectin 39
Oclacitinib Maleate 37
Gabapentin 34
Spinosad 33
Famotidine 33
Enrofloxacin 32
Fluralaner Chew Tablets 32
Ursodiol 29
Buprenorphine 27
Fluralaner 13.64% 12-Week Chew 26
Afoxolaner 24
Grapiprant 24
Tramadol 22
Sam-E, Silybin, Vitamin E, Zinc 22
Bedinvetmab 22

Gall bladder & bile duct disorder NOS Reaction Insights

837 reports name Gall bladder & bile duct disorder NOS; 280 recorded a death outcome (33.5% of reported events, not a population-level mortality rate). VeDDRA code: 480.

By species: Dog (786 reports), Cat (48 reports), Cattle (1 reports). By breed: Retriever - Labrador (82), Crossbred Canine/dog (62), Chihuahua (35).

Most co-reported drugs: Trilostane (187 reports), Carprofen (128 reports), Maropitant Citrate (121 reports), Milbemycin Oxime + Spinosad (84 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.