Reaction profile

The FDA adverse-event record for illness nos

173 FDA adverse-event reports reference illness nos (VeDDRA 99950). See the species, breeds, and drugs most associated with it below.

173
reports citing this reaction
18.5%
death-coded share
Dog
most-affected species
Hyaluronate Sodium
most-associated drug
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173
Total Reports
32
Deaths
18.5%
Death Rate

Species Most Affected

Dog 95
Horse 54
Cattle 10
Cat 9
Pig 2
Chicken 1
Sheep 1
Unknown 1

Breeds Most Affected

Unknown 37
Dog (unknown) 24
Retriever - Labrador 9
Horse (unknown) 8
Retriever - Golden 7
Domestic Shorthair 6
Chihuahua 6
Holstein-Friesian also known as Holstein 4
Crossbred Canine/dog 4
Terrier - Yorkshire 4

Associated Drugs

Hyaluronate Sodium 46
Milbemycin Oxime + Spinosad 22
Spinosad 13
Ivermectin + Pyrantel As Pamoate Salt 10
Monensin Sodium 5
Oclacitinib Maleate 5
Imidacloprid + Moxidectin 4
Cefovecin 3
Lufenuron + Milbemycin Oxime 3
Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg 3
Ivermectin/Pyrantel Pamoate Chewable 68Mcg/163Mg 3
Firocoxib 227 Mg Chewable 3
Carprofen 3
Fluralaner 3
Milbemycin Oxime, Lufenuron 3
Polysulfated Glycosaminoglycan 3
Tulathromycin 2
Bovine Parainfluenza Virus 3, Reisinger(Nl-Bk-6), Mlv; Bovine Respiratory Syncyt 2
Ivermectin(1%)/Clorsulon(10%) Injection 2
Doxycycline 2

Illness NOS Reaction Insights

173 reports name Illness NOS; 32 recorded a death outcome (18.5% of reported events, not a population-level mortality rate). VeDDRA code: 99950.

By species: Dog (95 reports), Horse (54 reports), Cattle (10 reports). By breed: Unknown (37), Dog (unknown) (24), Retriever - Labrador (9).

Most co-reported drugs: Hyaluronate Sodium (46 reports), Milbemycin Oxime + Spinosad (22 reports), Spinosad (13 reports), Ivermectin + Pyrantel As Pamoate Salt (10 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.