Reaction profile

The FDA adverse-event record for increased packed cell volume (pcv)

674 FDA adverse-event reports reference increased packed cell volume (pcv) (VeDDRA 2419). See the species, breeds, and drugs most associated with it below.

674
reports citing this reaction
18.2%
death-coded share
Dog
most-affected species
Maropitant Citrate
most-associated drug
Verify with FDA CVM →
674
Total Reports
123
Deaths
18.2%
Death Rate

Species Most Affected

Dog 591
Cat 66
Horse 16
Ferret 1

Breeds Most Affected

Retriever - Labrador 66
Crossbred Canine/dog 48
Domestic Shorthair 44
Terrier - Yorkshire 36
Chihuahua 22
Beagle 19
Maltese 18
Terrier - Boston 17
Shih Tzu 17
Dachshund (unspecified) 16

Associated Drugs

Maropitant Citrate 90
Carprofen 79
Moxidectin 71
Fluralaner Chew Tablets 70
Trilostane 63
Oclacitinib Maleate 48
Gabapentin 33
Afoxolaner 32
Fluralaner 13.64% 12-Week Chew 30
Metronidazole 28
Sarolaner 27
Ivermectin + Pyrantel As Pamoate Salt 26
Milbemycin Oxime + Spinosad 25
Famotidine 23
Meloxicam 23
Buprenorphine 22
Pyrantel Pamoate;Sarolaner 21
Enrofloxacin 20
Melarsomine Dihydrochloride 19
Grapiprant 18

Increased packed cell volume (PCV) Reaction Insights

674 reports name Increased packed cell volume (PCV); 123 recorded a death outcome (18.2% of reported events, not a population-level mortality rate). VeDDRA code: 2419.

By species: Dog (591 reports), Cat (66 reports), Horse (16 reports). By breed: Retriever - Labrador (66), Crossbred Canine/dog (48), Domestic Shorthair (44).

Most co-reported drugs: Maropitant Citrate (90 reports), Carprofen (79 reports), Moxidectin (71 reports), Fluralaner Chew Tablets (70 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.