Reaction profile

The FDA adverse-event record for angioedema

161 FDA adverse-event reports reference angioedema (VeDDRA 516). See the species, breeds, and drugs most associated with it below.

161
reports citing this reaction
0.6%
death-coded share
Dog
most-affected species
Moxidectin
most-associated drug
Verify with FDA CVM →
161
Total Reports
1
Deaths
0.6%
Death Rate

Species Most Affected

Dog 153
Cat 5
Horse 3

Breeds Most Affected

Retriever - Labrador 20
Boxer (German Boxer) 15
Terrier - Bull - American Pit 12
Chihuahua 11
Dachshund (unspecified) 8
Bulldog - French 7
Shepherd Dog - German 6
Dog (unknown) 5
Shepherd Dog - Australian 4
Domestic Shorthair 4

Associated Drugs

Moxidectin 50
Afoxolaner 15
Melarsomine Dihydrochloride 15
Maropitant Citrate 11
Milbemycin Oxime + Spinosad 10
Ivermectin + Pyrantel As Pamoate Salt 10
Diphenhydramine Hcl 9
Melarsomine Dihydrochloride Injection 8
Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St 8
Dexamethasone 7
Oclacitinib Maleate 7
Anti-Il31 Mab Mcs Lot #1283563 7
Dexmedetomidine Hydrochloride 5
Cefovecin 5
Pyrantel Pamoate 5
Bordetella Bronchiseptica 92B 012992-7 Strain Boehringer Ingelheim 5
Rabies Virus, Kv 5
Prednisone 5
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 5
Isoflurane 4

Angioedema Reaction Insights

161 reports name Angioedema; 1 recorded a death outcome (0.6% of reported events, not a population-level mortality rate). VeDDRA code: 516.

By species: Dog (153 reports), Cat (5 reports), Horse (3 reports). By breed: Retriever - Labrador (20), Boxer (German Boxer) (15), Terrier - Bull - American Pit (12).

Most co-reported drugs: Moxidectin (50 reports), Afoxolaner (15 reports), Melarsomine Dihydrochloride (15 reports), Maropitant Citrate (11 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.