Reaction profile

The FDA adverse-event record for angioedema

173 FDA adverse-event reports reference angioedema (VeDDRA 516). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1113 of 2,481
by report volume (all reactions)
173
reports citing this reaction
1.2%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Angioedema has 173 reports now versus 166 in that prior snapshot: 7 more (4.2%).

Report change
+7
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Angioedema changes

FDA AER · VeDDRA plate

Code 516 VOL-LOW

VOL-LOW · DEATH-LOW · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 173 reports
  • DEATH-LOW 1.2%
  • MID-PACK #1113/2481
  • PHOTO-FINISH Illness NOS
  • SPECIES-DOG Dog · 164
  • DRUG-LEAD Moxidectin · 53
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Illness NOS (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Angioedema

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Cough, productive · near174Decreased blood urea… · near174Paraparesis · near174Angioedema · this reaction173Illness NOS · near173Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Angioedema

Angioedema: low death-coded share in the FDA AER plate

Signature read: Angioedema's 1.2% death-coded share is among the lowest in the openFDA reaction corpus. Report volume sits in the middle third of the reaction corpus. Death-coded share is lower-third: 2 of 173 reports (1.2% of named reports). Nearest volume peer: Illness NOS (±0 reports). Lead species Dog (164). Lead co-reported drug Moxidectin (53).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Moxidectin appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 164
Cat 6
Horse 3

Breeds Most Affected

Retriever - Labrador 22
Boxer (German Boxer) 15
Terrier - Bull - American Pit 13
Chihuahua 12
Bulldog - French 9
Dachshund (unspecified) 8
Shepherd Dog - German 6
Shepherd Dog - Australian 5
Dog (unknown) 5
Domestic Shorthair 4

Associated Drugs

Moxidectin 53
Melarsomine Dihydrochloride 17
Afoxolaner 15
Maropitant Citrate 13
Milbemycin Oxime + Spinosad 10
Ivermectin + Pyrantel As Pamoate Salt 10
Diphenhydramine Hcl 9
Melarsomine Dihydrochloride Injection 8
Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St 8
Oclacitinib Maleate 8
Anti-Il31 Mab Mcs Lot #1283563 8
Prednisone 8
Dexamethasone 7
Buprenorphine 7
Ivermectin 6
Dexmedetomidine Hydrochloride 5
Cefovecin 5
Isoflurane 5
Pyrantel Pamoate 5
Bordetella Bronchiseptica 92B 012992-7 Strain Boehringer Ingelheim 5

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Angioedema, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (173 here).

Similar death-coded share

Nearest other reactions by death-coded share (1.2% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Angioedema (#1113 of 2,481 by report volume); death-coded 1.2%. PlainBreed reaction plate · death-coded share stamp 1.2% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →