Reaction profile

The FDA adverse-event record for hypophosphataemia

764 FDA reports name hypophosphataemia, a high-volume reaction in the CVM extract (VeDDRA 2242). Plate stamps and neighbourhood peers follow.

#477 of 2,481
by report volume (all reactions)
764
reports citing this reaction
20.5%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Hypophosphataemia has 764 reports now versus 729 in that prior snapshot: 35 more (4.8%).

Report change
+35
Death-coded reports
+7
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Hypophosphataemia changes

FDA AER · VeDDRA plate

Code 2242 VOL-MID

VOL-MID · DEATH-HOT · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 764 reports
  • DEATH-HOT 20.5%
  • UPPER-Q #477/2481
  • PHOTO-FINISH Application site swel…
  • SPECIES-DOG Dog · 543
  • DRUG-LEAD Maropitant Citrate · 85
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Application site swelling (±0 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Hypophosphataemia

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Application site swel… · near764Hypophosphataemia · this rea…764Swollen eye · near763Colic · near762INEFFECTIVE, GASTRIC… · near762Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Hypophosphataemia

What the FDA AER plate says about Hypophosphataemia

Signature read: 157 death-coded reports is a heavy tail count for Hypophosphataemia in the CVM extract. Report volume is upper-third scale: 764 named reports in the openFDA extract. 157 of 764 reports were death-coded (20.5% of named reports, not a population mortality rate). Nearest volume peer: Application site swelling (±0 reports). Lead species Dog (543). Lead co-reported drug Maropitant Citrate (85).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Maropitant Citrate appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 543
Cat 195
Horse 17
Cattle 8
Pig 1

Breeds Most Affected

Domestic Shorthair 124
Crossbred Canine/dog 50
Retriever - Labrador 46
Chihuahua 32
Retriever - Golden 28
Shepherd Dog - Australian 24
Shih Tzu 21
Shepherd Dog - German 21
Terrier - Yorkshire 19
Domestic Longhair 19

Associated Drugs

Maropitant Citrate 85
Milbemycin Oxime + Spinosad 52
Carprofen 51
Afoxolaner 49
Oclacitinib Maleate 46
Velagliflozin Proline Monohydrate 42
Fluralaner Chew Tablets 41
Moxidectin 35
Fluralaner 13.64% 12-Week Chew 29
Spinosad 28
Ivermectin + Pyrantel As Pamoate Salt 26
Gabapentin 26
Bexagliflozin 26
Bedinvetmab 25
Buprenorphine 23
Cefovecin 23
Trilostane 23
Fluid Therapy 23
Milbemycin Oxime + Praziquantel 22
Pyrantel Pamoate;Sarolaner 22

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Hypophosphataemia, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (764 here).

Similar death-coded share

Nearest other reactions by death-coded share (20.5% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Hypophosphataemia (#477 of 2,481 by report volume); death-coded 20.5%. PlainBreed reaction plate · death-coded report count stamp 157 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →