Reaction profile

The FDA adverse-event record for hypophosphataemia

688 FDA adverse-event reports reference hypophosphataemia (VeDDRA 2242). See the species, breeds, and drugs most associated with it below.

688
reports citing this reaction
20.3%
death-coded share
Dog
most-affected species
Maropitant Citrate
most-associated drug
Verify with FDA CVM →
688
Total Reports
140
Deaths
20.3%
Death Rate

Species Most Affected

Dog 504
Cat 163
Horse 12
Cattle 8
Pig 1

Breeds Most Affected

Domestic Shorthair 100
Crossbred Canine/dog 50
Retriever - Labrador 43
Chihuahua 30
Retriever - Golden 26
Shepherd Dog - Australian 24
Shih Tzu 21
Terrier - Yorkshire 18
Shepherd Dog - German 17
Domestic Longhair 16

Associated Drugs

Maropitant Citrate 67
Milbemycin Oxime + Spinosad 52
Carprofen 47
Afoxolaner 43
Fluralaner Chew Tablets 41
Oclacitinib Maleate 35
Moxidectin 34
Velagliflozin Proline Monohydrate 30
Spinosad 28
Ivermectin + Pyrantel As Pamoate Salt 24
Cefovecin 23
Trilostane 23
Fluralaner 13.64% 12-Week Chew 22
Buprenorphine 21
Bexagliflozin 21
Fluid Therapy 20
Bedinvetmab 20
Milbemycin Oxime + Praziquantel 19
Gabapentin 19
Pyrantel Pamoate;Sarolaner 19

Hypophosphataemia Reaction Insights

688 reports name Hypophosphataemia; 140 recorded a death outcome (20.3% of reported events, not a population-level mortality rate). VeDDRA code: 2242.

By species: Dog (504 reports), Cat (163 reports), Horse (12 reports). By breed: Domestic Shorthair (100), Crossbred Canine/dog (50), Retriever - Labrador (43).

Most co-reported drugs: Maropitant Citrate (67 reports), Milbemycin Oxime + Spinosad (52 reports), Carprofen (47 reports), Afoxolaner (43 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.