Reaction profile

The FDA adverse-event record for swollen eye

746 FDA adverse-event reports reference swollen eye (VeDDRA 1810). See the species, breeds, and drugs most associated with it below.

746
reports citing this reaction
5.6%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
746
Total Reports
42
Deaths
5.6%
Death Rate

Species Most Affected

Dog 603
Cat 79
Human 42
Cattle 13
Horse 6
Other Bovine 1
Turkey 1
Chicken 1

Breeds Most Affected

Retriever - Labrador 60
Unknown 45
Boxer (German Boxer) 42
Domestic Shorthair 40
Crossbred Canine/dog 39
Chihuahua 33
Shepherd Dog - German 24
Pit Bull 22
Retriever - Golden 22
Shih Tzu 21

Associated Drugs

Milbemycin Oxime + Spinosad 98
Moxidectin 85
Afoxolaner 53
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 35
Maropitant Citrate 34
Oclacitinib Maleate 31
Milbemycin Oxime + Praziquantel 26
Anti-Il31 Mab Mcs Lot #1283563 25
Gabapentin 22
Diphenhydramine 21
Prednisone 20
Carprofen 20
Ivermectin + Pyrantel As Pamoate Salt 20
Sarolaner 19
Pyrantel Pamoate;Sarolaner 19
Fluralaner Chew Tablets 18
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 17
Lotilaner 17
Selamectin 16
Spinosad 16

Swollen eye Reaction Insights

746 reports name Swollen eye; 42 recorded a death outcome (5.6% of reported events, not a population-level mortality rate). VeDDRA code: 1810.

By species: Dog (603 reports), Cat (79 reports), Human (42 reports). By breed: Retriever - Labrador (60), Unknown (45), Boxer (German Boxer) (42).

Most co-reported drugs: Milbemycin Oxime + Spinosad (98 reports), Moxidectin (85 reports), Afoxolaner (53 reports), Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride (35 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.