Reaction profile

The FDA adverse-event record for stress leukogram

181 FDA adverse-event reports reference stress leukogram (VeDDRA 2589). See the species, breeds, and drugs most associated with it below.

181
reports citing this reaction
22.7%
death-coded share
Dog
most-affected species
Trilostane
most-associated drug
Verify with FDA CVM →
181
Total Reports
41
Deaths
22.7%
Death Rate

Species Most Affected

Dog 153
Cat 23
Horse 5

Breeds Most Affected

Domestic Shorthair 16
Retriever - Labrador 14
Crossbred Canine/dog 12
Retriever - Golden 9
Chihuahua 7
Shih Tzu 6
Boxer (German Boxer) 6
Shepherd Dog - German 6
Beagle 4
American Pit Bull Terrier 4

Associated Drugs

Trilostane 51
Maropitant Citrate 17
Fluralaner Chew Tablets 15
Gabapentin 14
Grapiprant 11
Milbemycin Oxime + Praziquantel 10
Oclacitinib Maleate 9
Prednisone 9
Moxidectin 9
Afoxolaner 8
Carprofen 8
Milbemycin Oxime + Spinosad 7
Pyrantel Pamoate;Sarolaner 7
Bedinvetmab 7
Melarsomine Dihydrochloride 6
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 6
Diphenhydramine 5
Bordetella Vaccine 5
Doxycycline 5
Furosemide 5

Stress leukogram Reaction Insights

181 reports name Stress leukogram; 41 recorded a death outcome (22.7% of reported events, not a population-level mortality rate). VeDDRA code: 2589.

By species: Dog (153 reports), Cat (23 reports), Horse (5 reports). By breed: Domestic Shorthair (16), Retriever - Labrador (14), Crossbred Canine/dog (12).

Most co-reported drugs: Trilostane (51 reports), Maropitant Citrate (17 reports), Fluralaner Chew Tablets (15 reports), Gabapentin (14 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.