Reaction profile

The FDA adverse-event record for joint ligament disorder nos

110 FDA adverse-event reports reference joint ligament disorder nos (VeDDRA 2465). See the species, breeds, and drugs most associated with it below.

110
reports citing this reaction
10.0%
death-coded share
Dog
most-affected species
Trilostane
most-associated drug
Verify with FDA CVM →
110
Total Reports
11
Deaths
10.0%
Death Rate

Species Most Affected

Dog 107
Horse 2
Cat 1

Breeds Most Affected

Retriever - Labrador 10
Crossbred Canine/dog 9
Beagle 6
Boxer (German Boxer) 6
Shepherd Dog - German 5
Bulldog 4
Retriever - Golden 4
Terrier - Yorkshire 3
Poodle (unspecified) 3
Dog (unknown) 3

Associated Drugs

Trilostane 29
Bedinvetmab 22
Oclacitinib Maleate 19
Carprofen 13
Gabapentin 11
Milbemycin Oxime + Spinosad 10
Fluralaner Chew Tablets 10
Grapiprant 9
Milbemycin Oxime + Praziquantel 6
Polysulfated Glycosaminoglycan 5
Methocarbamol 4
Deracoxib 4
Fluralaner 13.64% 12-Week Chew 4
Galliprant 4
Enrofloxacin 3
Famotidine 3
Prednisone 3
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 3
Firocoxib 3
Selamectin 2

Joint ligament disorder NOS Reaction Insights

110 reports name Joint ligament disorder NOS; 11 recorded a death outcome (10.0% of reported events, not a population-level mortality rate). VeDDRA code: 2465.

By species: Dog (107 reports), Horse (2 reports), Cat (1 reports). By breed: Retriever - Labrador (10), Crossbred Canine/dog (9), Beagle (6).

Most co-reported drugs: Trilostane (29 reports), Bedinvetmab (22 reports), Oclacitinib Maleate (19 reports), Carprofen (13 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.