Reaction profile

The FDA adverse-event record for joint ligament disorder nos

123 FDA adverse-event reports reference joint ligament disorder nos (VeDDRA 2465). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1292 of 2,481
by report volume (all reactions)
123
reports citing this reaction
10.6%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Joint ligament disorder NOS has 123 reports now versus 117 in that prior snapshot: 6 more (5.1%).

Report change
+6
Death-coded reports
+1
Death-coded share
+0.3 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Joint ligament disorder NOS changes

FDA AER · VeDDRA plate

Code 2465 VOL-LOW

VOL-LOW · DEATH-ELEV · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 123 reports
  • DEATH-ELEV 10.6%
  • MID-PACK #1292/2481
  • PHOTO-FINISH Birth defect
  • SPECIES-DOG Dog · 115
  • DRUG-LEAD Trilostane · 29
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Birth defect (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Joint ligament disorder NOS

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Birth defect · near123Hypomagnesaemic condi… · near123Joint ligament disord… · thi…123Lens disorder NOS · near123Lung tumour · near123Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Joint ligament disorder NOS

What the FDA AER plate says about Joint ligament disorder NOS

Signature read: death-coded share at 10.6% is the most distinctive outcome stamp on Joint ligament disorder NOS. Report volume sits in the middle third of the reaction corpus. 13 of 123 reports were death-coded (10.6% of named reports, not a population mortality rate). Nearest volume peer: Birth defect (±0 reports). Lead species Dog (115). Lead co-reported drug Trilostane (29).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Trilostane appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 115
Horse 5
Cat 3

Breeds Most Affected

Retriever - Labrador 14
Crossbred Canine/dog 11
Shepherd Dog - German 6
Beagle 6
Boxer (German Boxer) 6
Retriever - Golden 5
Bulldog 4
Terrier - Yorkshire 3
Poodle (unspecified) 3
Dog (unknown) 3

Associated Drugs

Trilostane 29
Bedinvetmab 24
Oclacitinib Maleate 19
Carprofen 15
Gabapentin 14
Milbemycin Oxime + Spinosad 10
Fluralaner Chew Tablets 10
Grapiprant 9
Prednisone 7
Milbemycin Oxime + Praziquantel 7
Famotidine 6
Maropitant Citrate 5
Fluralaner 13.64% 12-Week Chew 5
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 5
Methocarbamol 4
Polysulfated Glycosaminoglycan 4
Deracoxib 4
Galliprant 4
Enrofloxacin 3
Fluralaner 3

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Joint ligament disorder NOS, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (123 here).

Similar death-coded share

Nearest other reactions by death-coded share (10.6% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Joint ligament disorder NOS (#1292 of 2,481 by report volume); death-coded 10.6%. PlainBreed reaction plate · death-coded share stamp 10.6% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →