Reaction profile

The FDA adverse-event record for cutaneous oedema

77 FDA adverse-event reports reference cutaneous oedema (VeDDRA 1204). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1516 of 2,481
by report volume (all reactions)
77
reports citing this reaction
26.0%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Cutaneous oedema has 77 reports now versus 76 in that prior snapshot: 1 more (1.3%).

Report change
+1
Death-coded reports
+0
Death-coded share
−0.3 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Cutaneous oedema changes

FDA AER · VeDDRA plate

Code 1204 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 77 reports
  • DEATH-HOT 26.0%
  • MID-PACK #1516/2481
  • PHOTO-FINISH Application site twit…
  • SPECIES-DOG Dog · 56
  • DRUG-LEAD Maropitant Citrate · 11
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Application site twitching (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Report-volume neighbourhood around Cutaneous oedema

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Application site twit… · near77Cutaneous oedema · this reac…77Dermal plaque · near77Drug preparation error · near77INEFFECTIVE, APPETITE… · near77Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Cutaneous oedema

Cutaneous oedema: high death-coded share in the FDA AER plate

Signature read: Cutaneous oedema's 26.0% death-coded share is among the highest in the openFDA reaction corpus. Report volume sits in the middle third of the reaction corpus. Death-coded share is upper-third: 20 of 77 reports (26.0% of named reports). Nearest volume peer: Application site twitching (±0 reports). Lead species Dog (56). Lead co-reported drug Maropitant Citrate (11).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 56
Cat 9
Horse 6
Cattle 5
Human 1

Breeds Most Affected

Retriever - Labrador 9
Domestic Shorthair 6
Crossbred Canine/dog 5
Retriever - Golden 5
Shepherd Dog - German 4
Chihuahua 3
Holstein-Friesian also known as Holstein 2
Quarter Horse 2
Dog (unknown) 2
Thoroughbred 2

Associated Drugs

Maropitant Citrate 11
Afoxolaner 9
Gabapentin 7
Carprofen 6
Meloxicam 4
Deracoxib 4
Isoflurane 4
Prednisone 4
Doxycycline 4
Cyclosporine 4
Tigilanol Tiglate 4
Bedinvetmab 4
Ceftiofur Crystalline Free Acid 3
Enrofloxacin 3
Milbemycin Oxime + Spinosad 3
Ivermectin + Pyrantel As Pamoate Salt 3
Moxidectin 3
Cefpodoxime Proxetil 3
Dexmedetomidine 3
Tramadol 3

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Cutaneous oedema, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (26.0% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Cutaneous oedema (#1516 of 2,481 by report volume); death-coded 26.0%. PlainBreed reaction plate · death-coded share stamp 26.0% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →