Reaction profile

The FDA adverse-event record for alkalosis

81 FDA adverse-event reports reference alkalosis (VeDDRA 2075). See the species, breeds, and drugs most associated with it below.

81
reports citing this reaction
25.9%
death-coded share
Dog
most-affected species
Gabapentin
most-associated drug
Verify with FDA CVM →
81
Total Reports
21
Deaths
25.9%
Death Rate

Species Most Affected

Dog 55
Cat 20
Horse 5
Donkey 1

Breeds Most Affected

Domestic Shorthair 12
Retriever - Labrador 9
Quarter Horse 3
Bulldog - French 3
Retriever - Golden 3
Crossbred Canine/dog 3
Schnauzer - Miniature 2
Shepherd Dog - German 2
Shepherd Dog - Australian 2
Domestic Longhair 2

Associated Drugs

Gabapentin 13
Maropitant Citrate 11
Carprofen 10
Buprenorphine 9
Milbemycin Oxime + Spinosad 8
Enrofloxacin 8
Bexagliflozin 7
Afoxolaner 6
Oxygen 6
Fluid Therapy 6
Ampicillin Sodium/Sulbactam Sodium 5
Ivermectin + Pyrantel As Pamoate Salt 4
Propofol 4
Isoflurane 4
Trilostane 4
Lotilaner 4
Rabies Vaccine 4
Maropitant 4
Deracoxib 4
Robenacoxib 4

Alkalosis Reaction Insights

81 reports name Alkalosis; 21 recorded a death outcome (25.9% of reported events, not a population-level mortality rate). VeDDRA code: 2075.

By species: Dog (55 reports), Cat (20 reports), Horse (5 reports). By breed: Domestic Shorthair (12), Retriever - Labrador (9), Quarter Horse (3).

Most co-reported drugs: Gabapentin (13 reports), Maropitant Citrate (11 reports), Carprofen (10 reports), Buprenorphine (9 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.