Reaction profile

The FDA adverse-event record for hyperventilation

246 FDA adverse-event reports reference hyperventilation (VeDDRA 1177). See the species, breeds, and drugs most associated with it below.

246
reports citing this reaction
13.0%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
246
Total Reports
32
Deaths
13.0%
Death Rate

Species Most Affected

Dog 177
Cat 44
Horse 23
Cattle 1
Human 1

Breeds Most Affected

Domestic Shorthair 23
Crossbred Canine/dog 15
Retriever - Labrador 15
Dog (unknown) 12
Domestic Longhair 8
Quarter Horse 8
Boxer (German Boxer) 7
Dachshund (unspecified) 7
Terrier - Yorkshire 6
Shepherd Dog - German 6

Associated Drugs

Milbemycin Oxime + Spinosad 16
Nitenpyram 14
Afoxolaner 13
Butorphanol 12
Moxidectin 12
Carprofen 11
Detomidine Hydrochloride 11
Spinosad 10
Cefovecin 10
Fluralaner 13.64% 12-Week Chew 10
Propofol 9
Dexmedetomidine Hydrochloride 8
Bedinvetmab 8
Selamectin 7
Ivermectin + Pyrantel As Pamoate Salt 7
Butorphanol Tartrate 7
Isoflurane 6
Gabapentin 6
Rabies Vaccine 5
Tramadol 5

Hyperventilation Reaction Insights

246 reports name Hyperventilation; 32 recorded a death outcome (13.0% of reported events, not a population-level mortality rate). VeDDRA code: 1177.

By species: Dog (177 reports), Cat (44 reports), Horse (23 reports). By breed: Domestic Shorthair (23), Crossbred Canine/dog (15), Retriever - Labrador (15).

Most co-reported drugs: Milbemycin Oxime + Spinosad (16 reports), Nitenpyram (14 reports), Afoxolaner (13 reports), Butorphanol (12 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.