Reaction profile

The FDA adverse-event record for injection site infection

243 FDA adverse-event reports reference injection site infection (VeDDRA 1542). See the species, breeds, and drugs most associated with it below.

243
reports citing this reaction
14.4%
death-coded share
Dog
most-affected species
Tigilanol Tiglate
most-associated drug
Verify with FDA CVM →
243
Total Reports
35
Deaths
14.4%
Death Rate

Species Most Affected

Dog 183
Cattle 22
Horse 22
Cat 13
Pig 2
Donkey 1

Breeds Most Affected

Retriever - Labrador 20
Dog (unknown) 18
Boxer (German Boxer) 11
Bulldog - French 10
Cattle (other) 9
Domestic Shorthair 7
Pit Bull 7
Terrier (unspecified) 7
Terrier - Bull - Staffordshire 7
Holstein-Friesian also known as Holstein 6

Associated Drugs

Tigilanol Tiglate 57
Carprofen 31
Gabapentin 31
Famotidine 27
Diphenhydramine 25
Dexmedetomidine 23
Prednisone 21
Maropitant Citrate 17
Dinoprost Tromethamine 16
Butorphanol 16
Moxidectin 14
Polysulfated Glycosaminoglycan 13
Bupivacaine Lipsome Injectable Suspension 13
Bupivacaine 13
Hydromorphone 11
Meloxicam 10
Buprenorphine 10
Bedinvetmab 10
Propofol 9
Dexmedetomidine Hydrochloride 9

Injection site infection Reaction Insights

243 reports name Injection site infection; 35 recorded a death outcome (14.4% of reported events, not a population-level mortality rate). VeDDRA code: 1542.

By species: Dog (183 reports), Cattle (22 reports), Horse (22 reports). By breed: Retriever - Labrador (20), Dog (unknown) (18), Boxer (German Boxer) (11).

Most co-reported drugs: Tigilanol Tiglate (57 reports), Carprofen (31 reports), Gabapentin (31 reports), Famotidine (27 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.