Reaction profile

The FDA adverse-event record for cardiac neoplasm

80 FDA adverse-event reports reference cardiac neoplasm (VeDDRA 2309). See the species, breeds, and drugs most associated with it below.

80
reports citing this reaction
67.5%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
80
Total Reports
54
Deaths
67.5%
Death Rate

Species Most Affected

Dog 77
Cat 3

Breeds Most Affected

Retriever - Labrador 8
Crossbred Canine/dog 7
Retriever - Golden 5
Bulldog 5
Dog (unknown) 5
Boxer (German Boxer) 4
Shepherd Dog - Australian 3
Pug 3
Terrier - Boston 3
Shih Tzu 2

Associated Drugs

Milbemycin Oxime + Spinosad 18
Oclacitinib Maleate 15
Fluralaner Chew Tablets 6
Spinosad 5
Maropitant Citrate 5
Imidacloprid + Moxidectin 4
Pimobendan 4
Ivermectin + Pyrantel As Pamoate Salt 4
Cyclosporine 3
Carprofen 3
Trilostane 3
Deracoxib 3
Diphenhydramine Hcl 3
Polysulfated Glycosaminoglycan 2
Prednisolone; Trimeprazine Tartrate 2
Thyroxine 2
Moxidectin 2
Afoxolaner 2
Metronidazole 2
Cefovecin 2

Cardiac neoplasm Reaction Insights

80 reports name Cardiac neoplasm; 54 recorded a death outcome (67.5% of reported events, not a population-level mortality rate). VeDDRA code: 2309.

By species: Dog (77 reports), Cat (3 reports). By breed: Retriever - Labrador (8), Crossbred Canine/dog (7), Retriever - Golden (5).

Most co-reported drugs: Milbemycin Oxime + Spinosad (18 reports), Oclacitinib Maleate (15 reports), Fluralaner Chew Tablets (6 reports), Spinosad (5 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.