Reaction profile

The FDA adverse-event record for inappropriate urination

5,684 FDA reports name inappropriate urination, a high-volume reaction in the CVM extract (VeDDRA 124). Plate stamps and neighbourhood peers follow.

#87 of 2,481
by report volume (all reactions)
5,684
reports citing this reaction
12.9%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Inappropriate urination has 5,684 reports now versus 5,586 in that prior snapshot: 98 more (1.8%).

Report change
+98
Death-coded reports
+8
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Inappropriate urination changes

FDA AER · VeDDRA plate

Code 124 VOL-HIGH

VOL-HIGH · DEATH-ELEV · TOP-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-HIGH 5,684 reports
  • DEATH-ELEV 12.9%
  • TOP-DECILE #87/2481
  • PHOTO-FINISH Agitation
  • SPECIES-DOG Dog · 4,697
  • DRUG-LEAD Bedinvetmab · 724
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Agitation (±17 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Inappropriate urination

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Elevated liver enzymes · near5735Inappropriate urinati… · thi…5684Agitation · near5667Anxiety · near5617Neutrophilia · near5573Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Inappropriate urination

What the FDA AER plate says about Inappropriate urination

Signature read: 735 death-coded reports is a heavy tail count for Inappropriate urination in the CVM extract. Report volume is upper-third scale: 5,684 named reports in the openFDA extract. 735 of 5,684 reports were death-coded (12.9% of named reports, not a population mortality rate). Nearest volume peer: Agitation (±17 reports). Lead species Dog (4,697). Lead co-reported drug Bedinvetmab (724).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Bedinvetmab appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 4,697
Cat 980
Unknown 2
Horse 2
Crustacea 1
Cattle 1
Rabbit 1

Breeds Most Affected

Domestic Shorthair 605
Retriever - Labrador 453
Crossbred Canine/dog 313
Retriever - Golden 204
Chihuahua 183
Boxer (German Boxer) 172
Shepherd Dog - German 162
Terrier - Yorkshire 141
Shih Tzu 136
Shepherd Dog - Australian 112

Associated Drugs

Bedinvetmab 724
Trilostane 628
Milbemycin Oxime + Spinosad 550
Afoxolaner 459
Oclacitinib Maleate 270
Carprofen 258
Fluralaner Chew Tablets 257
Ivermectin + Pyrantel As Pamoate Salt 246
Gabapentin 243
Pyrantel Pamoate;Sarolaner 241
Maropitant Citrate 211
Prednisone 185
Moxidectin 166
Spinosad 160
Frunevetmab 151
Fluralaner 13.64% 12-Week Chew 150
Milbemycin Oxime + Praziquantel 137
Cefovecin 132
Imidacloprid + Moxidectin 108
Grapiprant 104

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Inappropriate urination, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (5,684 here).

Similar death-coded share

Nearest other reactions by death-coded share (12.9% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Inappropriate urination (#87 of 2,481 by report volume); death-coded 12.9%. PlainBreed reaction plate · death-coded report count stamp 735 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →