Reaction profile

The FDA adverse-event record for inappropriate urination

5,422 FDA adverse-event reports reference inappropriate urination (VeDDRA 124). See the species, breeds, and drugs most associated with it below.

5,422
reports citing this reaction
13.0%
death-coded share
Dog
most-affected species
Bedinvetmab
most-associated drug
Verify with FDA CVM →
5,422
Total Reports
704
Deaths
13.0%
Death Rate

Species Most Affected

Dog 4,508
Cat 907
Unknown 2
Horse 2
Crustacea 1
Cattle 1
Rabbit 1

Breeds Most Affected

Domestic Shorthair 552
Retriever - Labrador 438
Crossbred Canine/dog 301
Retriever - Golden 196
Chihuahua 176
Boxer (German Boxer) 166
Shepherd Dog - German 156
Terrier - Yorkshire 137
Shih Tzu 133
Shepherd Dog - Australian 108

Associated Drugs

Bedinvetmab 671
Trilostane 604
Milbemycin Oxime + Spinosad 549
Afoxolaner 452
Fluralaner Chew Tablets 257
Oclacitinib Maleate 253
Carprofen 244
Ivermectin + Pyrantel As Pamoate Salt 243
Pyrantel Pamoate;Sarolaner 217
Gabapentin 213
Maropitant Citrate 197
Prednisone 175
Spinosad 160
Moxidectin 155
Fluralaner 13.64% 12-Week Chew 145
Milbemycin Oxime + Praziquantel 135
Cefovecin 128
Frunevetmab 125
Imidacloprid + Moxidectin 107
Grapiprant 97

Inappropriate urination Reaction Insights

5,422 reports name Inappropriate urination; 704 recorded a death outcome (13.0% of reported events, not a population-level mortality rate). VeDDRA code: 124.

By species: Dog (4,508 reports), Cat (907 reports), Unknown (2 reports). By breed: Domestic Shorthair (552), Retriever - Labrador (438), Crossbred Canine/dog (301).

Most co-reported drugs: Bedinvetmab (671 reports), Trilostane (604 reports), Milbemycin Oxime + Spinosad (549 reports), Afoxolaner (452 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.