Reaction profile

The FDA adverse-event record for decreased bowel movements

790 FDA adverse-event reports reference decreased bowel movements (VeDDRA 1939). See the species, breeds, and drugs most associated with it below.

790
reports citing this reaction
16.7%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
790
Total Reports
132
Deaths
16.7%
Death Rate

Species Most Affected

Dog 542
Cat 226
Horse 15
Rabbit 2
Unknown 1
Other Rodents 1
Human 1
Other Equids 1
Sheep 1

Breeds Most Affected

Domestic Shorthair 130
Chihuahua 45
Crossbred Canine/dog 45
Retriever - Labrador 42
Domestic Longhair 26
Terrier - Yorkshire 25
Shih Tzu 24
Domestic Mediumhair 21
Shepherd Dog - German 21
Retriever - Golden 20

Associated Drugs

Milbemycin Oxime + Spinosad 104
Maropitant Citrate 73
Carprofen 63
Afoxolaner 50
Cefovecin 43
Spinosad 37
Buprenorphine 35
Bedinvetmab 31
Famotidine 29
Gabapentin 28
Prednisone 27
Meloxicam 27
Ivermectin + Pyrantel As Pamoate Salt 25
Fluralaner 13.64% 12-Week Chew 23
Robenacoxib 21
Nitenpyram 21
Enrofloxacin 20
Imidacloprid + Moxidectin 18
Praziquantel 18
Fluralaner Chew Tablets 18

Decreased bowel movements Reaction Insights

790 reports name Decreased bowel movements; 132 recorded a death outcome (16.7% of reported events, not a population-level mortality rate). VeDDRA code: 1939.

By species: Dog (542 reports), Cat (226 reports), Horse (15 reports). By breed: Domestic Shorthair (130), Chihuahua (45), Crossbred Canine/dog (45).

Most co-reported drugs: Milbemycin Oxime + Spinosad (104 reports), Maropitant Citrate (73 reports), Carprofen (63 reports), Afoxolaner (50 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.