Reaction profile

The FDA adverse-event record for leucocytosis

57 FDA reports name leucocytosis, a lower-volume reaction in the CVM extract (VeDDRA 163). Plate stamps and neighbourhood peers follow.

#1675 of 2,481
by report volume (all reactions)
57
reports citing this reaction
17.5%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Leucocytosis has 57 reports now versus 57 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Leucocytosis changes

FDA AER · VeDDRA plate

Code 163 VOL-LOW

VOL-LOW · DEATH-ELEV · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 57 reports
  • DEATH-ELEV 17.5%
  • MID-PACK #1675/2481
  • PHOTO-FINISH Atrial fibrillation
  • SPECIES-DOG Dog · 57
  • DRUG-LEAD Milbemycin Oxime… · 17
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Atrial fibrillation (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Lower-volume neighbourhood around Leucocytosis

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Atrial fibrillation · near57Epistaxis (unilateral) · near57Eyelid lump · near57Lack of efficacy (bac… · near57Leucocytosis · this reaction57Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Leucocytosis

What the FDA AER plate says about Leucocytosis

Signature read: 57 reports place Leucocytosis in the lower third of FDA AER volume (#1675 of 2,481). Report volume is lower-third scale: 57 named reports in the openFDA extract. 10 of 57 reports were death-coded (17.5% of named reports, not a population mortality rate). Nearest volume peer: Atrial fibrillation (±0 reports). Lead species Dog (57). Lead co-reported drug Milbemycin Oxime + Spinosad (17).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 57

Breeds Most Affected

Retriever - Labrador 8
Shih Tzu 4
Siberian Husky 3
Terrier - Jack Russell 3
Boxer (German Boxer) 2
Crossbred Canine/dog 2
Deutsche Dogge, Great Dane 2
Mixed (Dog) 2
Dachshund (unspecified) 2
Collie - Border 1

Associated Drugs

Milbemycin Oxime + Spinosad 17
Ivermectin + Pyrantel As Pamoate Salt 5
Spinosad 4
Prednisone 4
Milbemycin Oxime, Lufenuron 3
Afoxolaner 3
Fluralaner Chew Tablets 3
Ivermectin + Pyrantel 3
Bordetella Vaccine 2
Metronidazole 2
Carprofen 2
Oclacitinib 2
Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St 2
Cefpodoxime Proxetil 2
Diphenhydramine Hcl 2
Milbemcyin Oxime, Lufenuron, Praziquantel 2
Sarolaner 2
Maropitant 2
Deracoxib 2
Lotilaner 2

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Leucocytosis, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (17.5% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Leucocytosis (#1675 of 2,481 by report volume); death-coded 17.5%. PlainBreed reaction plate · report volume stamp 57 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →