Reaction profile

The FDA adverse-event record for leucocytosis

57 FDA adverse-event reports reference leucocytosis (VeDDRA 163). See the species, breeds, and drugs most associated with it below.

57
reports citing this reaction
17.5%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
57
Total Reports
10
Deaths
17.5%
Death Rate

Species Most Affected

Dog 57

Breeds Most Affected

Retriever - Labrador 8
Shih Tzu 4
Siberian Husky 3
Terrier - Jack Russell 3
Boxer (German Boxer) 2
Crossbred Canine/dog 2
Mixed (Dog) 2
Deutsche Dogge, Great Dane 2
Dachshund (unspecified) 2
Collie - Border 1

Associated Drugs

Milbemycin Oxime + Spinosad 17
Ivermectin + Pyrantel As Pamoate Salt 5
Spinosad 4
Prednisone 4
Milbemycin Oxime, Lufenuron 3
Afoxolaner 3
Fluralaner Chew Tablets 3
Ivermectin + Pyrantel 3
Bordetella Vaccine 2
Metronidazole 2
Carprofen 2
Oclacitinib 2
Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St 2
Cefpodoxime Proxetil 2
Diphenhydramine Hcl 2
Milbemcyin Oxime, Lufenuron, Praziquantel 2
Sarolaner 2
Maropitant 2
Deracoxib 2
Lotilaner 2

Leucocytosis Reaction Insights

57 reports name Leucocytosis; 10 recorded a death outcome (17.5% of reported events, not a population-level mortality rate). VeDDRA code: 163.

By species: Dog (57 reports). By breed: Retriever - Labrador (8), Shih Tzu (4), Siberian Husky (3).

Most co-reported drugs: Milbemycin Oxime + Spinosad (17 reports), Ivermectin + Pyrantel As Pamoate Salt (5 reports), Spinosad (4 reports), Prednisone (4 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.