Reaction profile

The FDA adverse-event record for injection site serous discharge

135 FDA adverse-event reports reference injection site serous discharge (VeDDRA 105). See the species, breeds, and drugs most associated with it below.

135
reports citing this reaction
7.4%
death-coded share
Dog
most-affected species
Tigilanol Tiglate
most-associated drug
Verify with FDA CVM →
135
Total Reports
10
Deaths
7.4%
Death Rate

Species Most Affected

Dog 114
Horse 9
Cat 8
Cattle 2
Goat 1
Pig 1

Breeds Most Affected

Retriever - Labrador 12
Pit Bull 10
Domestic Shorthair 8
Boxer (German Boxer) 8
Dog (unknown) 7
Quarter Horse 5
Terrier - Bull - Staffordshire 5
Dachshund (unspecified) 4
Beagle 4
Shepherd Dog - German 3

Associated Drugs

Tigilanol Tiglate 56
Carprofen 19
Gabapentin 16
Maropitant Citrate 15
Diphenhydramine 14
Famotidine 12
Dexmedetomidine 11
Butorphanol 10
Propofol 9
Prednisone 9
Hydromorphone 8
Ceftiofur Crystalline Free Acid 7
Buprenorphine 7
Meloxicam 6
Atipamezole 6
Butorphanol Tartrate 6
Moxidectin 5
Bupivacaine Lipsome Injectable Suspension 5
Melarsomine Dihydrochloride 5
Bupivacaine 5

Injection site serous discharge Reaction Insights

135 reports name Injection site serous discharge; 10 recorded a death outcome (7.4% of reported events, not a population-level mortality rate). VeDDRA code: 105.

By species: Dog (114 reports), Horse (9 reports), Cat (8 reports). By breed: Retriever - Labrador (12), Pit Bull (10), Domestic Shorthair (8).

Most co-reported drugs: Tigilanol Tiglate (56 reports), Carprofen (19 reports), Gabapentin (16 reports), Maropitant Citrate (15 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.