Reaction profile

The FDA adverse-event record for erythema multiforme

79 FDA adverse-event reports reference erythema multiforme (VeDDRA 1197). See the species, breeds, and drugs most associated with it below.

79
reports citing this reaction
11.4%
death-coded share
Dog
most-affected species
Cefovecin
most-associated drug
Verify with FDA CVM →
79
Total Reports
9
Deaths
11.4%
Death Rate

Species Most Affected

Dog 73
Cat 6

Breeds Most Affected

Crossbred Canine/dog 6
Retriever - Labrador 6
Shih Tzu 5
Chihuahua 4
Schnauzer - Miniature 4
Collie - Border 3
Pinscher - Miniature 3
Domestic Shorthair 3
Boxer (German Boxer) 3
Siberian Husky 3

Associated Drugs

Cefovecin 9
Prednisone 8
Moxidectin 8
Milbemycin Oxime + Spinosad 7
Oclacitinib Maleate 6
Fluralaner Chew Tablets 5
Melarsomine Dihydrochloride 5
Anti-Il31 Mab Mcs Lot #1283563 5
Carprofen 4
Cefovecin Sodium 3
Levothyroxine Sodium 3
Cefpodoxime Proxetil 3
Cyclosporine 3
Doxycycline 3
Gabapentin 3
Firocoxib 2
Imidacloprid + Moxidectin 2
Tramadol 2
Selamectin 2
Cephalexin 2

Erythema multiforme Reaction Insights

79 reports name Erythema multiforme; 9 recorded a death outcome (11.4% of reported events, not a population-level mortality rate). VeDDRA code: 1197.

By species: Dog (73 reports), Cat (6 reports). By breed: Crossbred Canine/dog (6), Retriever - Labrador (6), Shih Tzu (5).

Most co-reported drugs: Cefovecin (9 reports), Prednisone (8 reports), Moxidectin (8 reports), Milbemycin Oxime + Spinosad (7 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.