Reaction profile

The FDA adverse-event record for atopic allergy nos (see also 'skin')

235 FDA adverse-event reports reference atopic allergy nos (see also 'skin') (VeDDRA 513). See the species, breeds, and drugs most associated with it below.

235
reports citing this reaction
3.0%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
235
Total Reports
7
Deaths
3.0%
Death Rate

Species Most Affected

Dog 223
Cat 10
Horse 1
Human 1

Breeds Most Affected

Retriever - Labrador 27
Crossbred Canine/dog 16
Shih Tzu 12
Retriever - Golden 10
Boxer (German Boxer) 9
Pit Bull 8
Shepherd Dog - German 7
Domestic Shorthair 7
Beagle 7
Terrier (unspecified) 7

Associated Drugs

Milbemycin Oxime + Spinosad 126
Milbemycin Oxime + Praziquantel 22
Spinosad 19
Trilostane 18
Fluralaner Chew Tablets 18
Imidacloprid + Moxidectin 17
Afoxolaner 10
Milbemycin Oxime 10
Oclacitinib Maleate 9
Cyclosporine 7
Prednisone 6
Cyclosporine A 6
Betamethasone + Florfenicol + Terbinafine 6
Grapiprant 6
Lotilaner 6
Fluralaner 13.64% 12-Week Chew 6
Ivermectin 5
Diphenhydramine 5
Moxidectin 5
Flumethrin-Imidacloprid 4

Atopic allergy NOS (see also 'Skin') Reaction Insights

235 reports name Atopic allergy NOS (see also 'Skin'); 7 recorded a death outcome (3.0% of reported events, not a population-level mortality rate). VeDDRA code: 513.

By species: Dog (223 reports), Cat (10 reports), Horse (1 reports). By breed: Retriever - Labrador (27), Crossbred Canine/dog (16), Shih Tzu (12).

Most co-reported drugs: Milbemycin Oxime + Spinosad (126 reports), Milbemycin Oxime + Praziquantel (22 reports), Spinosad (19 reports), Trilostane (18 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.